Results 91 to 100 of about 14,374 (222)

Synthesis, Characterization, and Biological Evaluation of Co(II), Cu(II), and Ni(II) Complexes With 2,2′‐Bipyridine‐5,5′‐Dicarboxamide Ligands: Antibacterial and Enzyme Inhibition Studies

ChemistryOpen, Volume 15, Issue 7, July 2026.
Synthesis of novel trinuclear [M3L2] complexes based on 5,5’‐regiochemistry is reported. Co‐L2 emerges as a potent lead with significant broad‐spectrum antibacterial activity. Ni‐L2 proves highly effective for pancreatic lipase and BChE inhibition, while the free L2 ligand exhibits superior AChE inhibitory potency.
İsmail Yılmaz, Müslüm Kuzu, Hasan Almohammed, Aseel Almadhoun, Hasan Solmaz, Raneem Mamoun Ali Nour   +5 more
wiley   +1 more source

Kinetics and mechanisms of acetylcholinesterase and butyrylcholinesterase inhibition by cardiovascular drugs and, benzodiazepines [PDF]

, 2014
The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrylcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and ...
Chiou, S.Y., Lin, L.Y., Lin, G.L., Lin, G., Tsai, Y.H., Lee, Y.R., Lai, G.W.   +6 more
core   +1 more source

Rethinking Alzheimer's Disease Therapy: From Amyloid‐Centric Approaches to Multi‐Target Phytochemical Strategies

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Alzheimer's disease is driven by interconnected pathological processes, including amyloid‐β aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, synaptic dysfunction, and mitochondrial impairment. While recently approved anti‐amyloid therapies represent an important advance, their modest clinical benefits highlight the ...
Emre Aktaş, İlay Yurt, Yağmur Nisa Cerlet, Haşmet Ayhan Hanağası   +3 more
wiley   +1 more source

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

Chemistry
Cholinesterases are enzymes that break down the neurotransmitter acetylcholine in the nervous system. The two main types are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE inhibitors are used to treat Alzheimer’s disease by increasing
Evdokiya Salamanova, Mariyana Atanasova, Irini Doytchinova   +2 more
doaj   +1 more source

Butyrylcholinesterase as a prognostic marker [PDF]

, 2018
Tato bakalářská práce se zabývá butyrylcholinesterázou jako jednou z hlavních lidských cholinesteráz. Podrobně popisuje jednotlivé cholinesterázy, jejich odlišnosti a mechanizmy účinku.
Šepsová, Klára
core  

Acetylcholinesterase and Butyrylcholinesterase – Important Enzymes of Human Body [PDF]

, 2004
The serine hydrolases and proteases are a ubiquitous group of enzymes that is fundamental to many critical lifefunctions. Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase.
Kamil Kuča, Jiří Patočka, Daniel Jun
core   +1 more source

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase

Molecules, 2019
A set of overall 40 carboxamides was prepared from five different natural occurring triterpenoids including oleanolic, ursolic, maslinic, betulinic, and platanic acid.
Anne Loesche, Michael Kahnt, Immo Serbian, Wolfgang Brandt, René Csuk   +4 more
doaj   +1 more source

Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Thiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Sandeep Bindra, Won Kyeong Jeong, Muzammil Kabier, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Harish Chandra vishwakarma, Della Grace Thomas Parambi, Naseer Maliyakkal, Sandeep Kumar, Leena K. Pappachen, Hoon Kim, Bijo Mathew   +11 more
wiley   +1 more source

The Potential Role of Cholinesterase in Diabetes Mellitus and Metabolic Syndrome [PDF]

المجلة العراقية للصيدلة
Background: Diabetes mellitus is the most prevalent chronic disease in the world, that is deadly or severely lowers quality of life and affects females more than males.
Muwafaq Zaya, Ahmed Mahmood
doaj   +1 more source

Regulation of attention and response to therapy in dementia by butyrylcholinesterase [PDF]

, 2003
Objectives: To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and the influence of butyrylcholinesterase on cognition.
Ballard CG, Saxby BK, Grace J, Swan AG, Fairbairn AF, Edwardson JA, McKeith IG, Ford GA, O'Brien KK, Wesnes K, O'Brien JT, Morris CM, Harrington F, Del Ser T   +13 more
core