Results 81 to 90 of about 14,314 (224)

Antennaria dioica (L.) Gaertn. (Asteraceae): From Metabolite Profiling to Comprehensive Evaluation of In Vitro and In Silico Enzyme Inhibitory Activity

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Antennaria dioica (L.) Gaertn. is a perennial herb from the tribe Gnaphalieae of the Asteraceae family. In‐depth phytochemical profiling and in vitro antioxidant and enzyme inhibition assessment of methanol‐aqueous extract from the A. dioica aerial parts were integrated with molecular docking study.
Dimitrina Zheleva‐Dimitrova, Gokhan Zengin, Iglika Lessigiarska, Ivanka Tsakovska, Radostina Nikolova‐Kejova, Ivayla Zheleva‐Kyuchukova, Georgi Momekov, Reneta Gevrenova   +7 more
wiley   +1 more source

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Molecules, 2017
Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the ...
Yang Gao, Liyi Geng, Vicky Ping Chen, Stephen Brimijoin   +3 more
doaj   +1 more source

Chemical Constituents and Biological Potentials of Teucrium scordium subsp. scordioides Extracts: In Vitro Experimental and In Silico Perspectives

ChemistryOpen, Volume 15, Issue 5, May 2026.
T. scordium subsp. scordioides may represent a natural source of antioxidants and enzyme inhibitors for use in different health‐promoting formulations. This study was undertaken to examine, for the first time, the antioxidant and enzyme inhibitory properties of several extracts obtained from the aerial parts of Teucrium scordium subsp.
Bengusu Hacer Akgul, Sakina Yagi, Mehmet Veysi Cetiz, Enver Saka, Gokhan Zengin, Eulogio J. Llorent‐Martínez, Marina Gómez‐Torres, Ismail Yapıcı, Ilhami Gulcin, Evren Yıldıztugay   +9 more
wiley   +1 more source

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

Chemistry
Cholinesterases are enzymes that break down the neurotransmitter acetylcholine in the nervous system. The two main types are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE inhibitors are used to treat Alzheimer’s disease by increasing
Evdokiya Salamanova, Mariyana Atanasova, Irini Doytchinova   +2 more
doaj   +1 more source

DEVELOPMENT OF BUTYRYLCHOLINESTERASE LIGANDS FOR THE IMAGING OF NEUROLOGICAL DISORDERS

, 2013
Butyrylcholinesterase (BuChE) is a serine hydrolase enzyme that, along with acetylcholinesterase (AChE), catalyzes the hydrolysis of acetylcholine. These enzymes are associated with the pathology of neurologic disorders such as Alzheimer's disease (AD)
Macdonald, Ian
core  

Organ‐Specific Phytochemical Composition and Bioactivity Profiling of Chaerophyllum aksekiense: A Multiassay Antioxidant, Enzyme Inhibition, and Correlation‐Based Evaluation

ChemistryOpen, Volume 15, Issue 5, May 2026.
This study reveals the organ‐specific phytochemical specialization of the endemic Chaerophyllum aksekiense for the first time. Although leaves exhibit the highest phenolic content and antioxidant capacity, flowers stand out with flavonoid accumulation, and roots demonstrate potent enzyme inhibition.
Bedrettin Selvi, Elif Aktürk Bozdemir
wiley   +1 more source

Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy

, 2017
We report herein the structure-based design and application of a fluorogenic butyrylcholinesterase probe that could discriminate butyrylcholinesterase from acetylcholinesterase.
Wen-Chao Yang, Guang-Fu Yang, Qi Sun, Hao Xiong, Shu-Hou Yang, Behrooz Moosavi, Shi-Yu Liu   +6 more
core   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus

, 1993
The activity of serum butyrylcholinesterase ('pseudocholinesterase', EC3.1.1.8) was investigated in 56 patients with type 1 diabetes mellitus, 51 patients with type 2 diabetes mellitus and 101 healthy control subjects.
Olukoga, A. O., Arrol, S., Gordon, C., Bhatnagar, D., Abbott, C. A., Durrington, P. N., Kumar, S., Boulton, A. J.M., MacKness, M. I.   +8 more
core   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source