Results 81 to 90 of about 14,374 (222)

From Metabolites to Mechanisms: Scorzonera parviflora Aerial Parts and Roots Extracts Profiled by UPLC‐ESI‐MS/MS, In Vitro/In Silico Tests, and Network Analysis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Scorzonera parviflora is considered a promising candidate for applications in the pharmaceutical, nutraceutical, and natural product industries. ABSTRACT In the present study, the extraction of Scorzonera parviflora aerial parts and roots was performed using four solvents, namely ethyl acetate (EA), ethanol, ethanol/water, and water. The total phenolic
Gokhan Zengin, Nilofar Nilofar, Gunes Ak, Eliana Fernandes, Luísa Custódio, Maria João Rodrigues, Shaza Aly, Omayma A. Eldahshan, Abdel Nasser Singab, Evren Yildiztugay, Milena Terzic, Meng‐Yao Li   +11 more
wiley   +1 more source

Butyrylcholinesterase as a biochemical marker

Bratislava Medical Journal, 2013
Butyrylcholinesterase (BChE) is an enzyme expressed in multiple organs and abundant in plasma. BChE can fluctuate in course of several reasons while both hypercholiensterasemia and hypocholinesterasemia are known. Considering evidence of BChE activity alterations, hepatocellular carcinoma, chronic liver diseases and poisoning with carbamates or ...
openaire   +3 more sources

Characterization of butyrylcholinesterase in bovine serum

Chemico-Biological Interactions, 2017
Human butyrylcholinesterase (HuBChE) protects from nerve agent toxicity. Our goal was to determine whether bovine serum could be used as a source of BChE. Bovine BChE (BoBChE) was immunopurified from 100 mL fetal bovine serum (FBS) or 380 mL adult bovine serum by binding to immobilized monoclonal mAb2.
Dafferner, Alicia J., Lushchekina, Sofya, Masson, Patrick, Xiao, Gaoping, Schopfer, Lawrence M., Lockridge, Oksana   +5 more
openaire   +2 more sources

Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana [PDF]

, 2016
To optimize the expression, extraction and purification of plant-derived tetrameric recombinant human butyrylcholinesterase (prBChE), we describe the development and use of plant viral amplicon-based gene expression system; Tobacco Mosaic Virus (TMV) RNA-
Salem Alkanaimsh, Somen Nandi, Arzola, Lucas, Karuppanan, Kalimuthu, Nandi, Somen, Bryce W. Falk, Hwang, Min Sook, Guerrero, Andrés, Kalimuthu Karuppanan, Tu, Aye M, McDonald, Karen A, Hashimoto, Bryce, Phu, My L, Aye M. Tu, My L. Phu, Falk, Bryce W, Dandekar, Abhaya M, Andrés Guerrero, Carlito B. Lebrilla, Abhaya M. Dandekar, Karen A. McDonald, Bryce Hashimoto, Min Sook Hwang, Lebrilla, Carlito B, Alkanaimsh, Salem, Raymond L. Rodriguez, Rodriguez, Raymond L, Lucas Arzola   +27 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Butyrylcholinesterase K variant and Alzheimer's disease [PDF]

, 1999
This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer’s disease. This was performed on an autopsy-confirmed series of patients with Alzheimer’s disease and controls.
Kakulas, B.A., Fabian, V., Vasikaran, S.D., Panegyres, P.K., Mamotte, C.D.S., Wilton, S.   +5 more
core  

Butyrylcholinesterase, variants and metabolic syndrome [PDF]

, 2018
Butyrylcholinesterase, a hepatic enzyme has a primarily pharmacological role in hydrolyzing esters. Variant forms of the enzymes exist. A hypothesis is presented for their continuing presence over evolution, and suggest a possible modulatory effect on ...
Sridhar, Gumpeny R.; Endocrine and Diabetes Centre, Krishnanagar, Visakhapatnam
core   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

Natural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato, Lucia Caputo, Laura De Martino, Daniela Grulova, Barbara Borczak, Joanna Kapusta‐Duch, Vincenzo De Feo   +6 more
wiley   +1 more source

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Molecules, 2017
Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the ...
Yang Gao, Liyi Geng, Vicky Ping Chen, Stephen Brimijoin   +3 more
doaj   +1 more source

Structure–activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor (IC50 ...
Chengyao Wu, Guijuan Zhang, Zai-Wei Zhang, Xia Jiang, Ziwen Zhang, Huanhuan Li, Hua-Li Qin, Wenjian Tang   +7 more
doaj   +1 more source