Results 61 to 70 of about 16,092 (168)

Phenolic Profiling and Bioactivity Evaluation of Stachys aleurites Extracts: LC–ESI–MS/MS Characterization, Antioxidant Capacity, and Enzyme Inhibitory Potential

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Solvent polarity shapes the phytochemical and bioactivity profile of Stachys aleurites. Methanol extraction enriches phenolics, especially verbascoside and chlorogenic acid, and enhances antioxidant and enzyme inhibitory activities, whereas the aqueous extract shows selective metal‐chelating and BChE inhibitory potential. ABSTRACT Natural products rich
Fatma Ozlem Kargin Solmaz, Cengiz Sarikurkcu, Bektaş Tepe   +2 more
wiley   +1 more source

Comparative Phytochemical and Biological Evaluation of Four Thymus Species From Türkiye for Dermocosmetic Applications

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Four Thymus species from Anatolia are profiled through molecular networking and multi‐target bioassays across skin‐relevant cellular models. Triterpene‐rich extracts inhibit key anti‐aging enzymes and promote wound closure in fibroblast, keratinocyte, and endothelial cells.
Ebru Özdemir Nath, Pierre‐Eric Campos, Audrey Le Cabec, Gül İpek Gündoğan, Diren Ergin, Ahsen Çetin, Sefa Sönmez, Emilie Destandau   +7 more
wiley   +1 more source

The Selectivity of Butyrylcholinesterase Inhibitors Revisited

Molecules
Acetylcholinesterase (AChE) inhibitors are the primary target for single-molecule anti-Alzheimer’s disease (AD) therapeutics. Though AChE has historically been the focus of investigation for small-molecule inhibitors, interest in another cholinergic ...
Michael D. Gambardella, Yigui Wang, Jiongdong Pang   +2 more
doaj   +1 more source

Structure–activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor (IC50 ...
Chengyao Wu, Guijuan Zhang, Zai-Wei Zhang, Xia Jiang, Ziwen Zhang, Huanhuan Li, Hua-Li Qin, Wenjian Tang   +7 more
doaj   +1 more source

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source

Bio‐Based Potential of Phenolic‐Rich Fabaceae Seeds (Gonocytisus angulatus, Podocytisus caramanicus): Chemical Standardization, Functional Screening, and Molecular Insights

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This study provides the first comparative phytochemical and functional evaluation of Gonocytisus angulatus and Podocytisus caramanicus seeds. Methanolic extracts showed richer phenolic profiles, while aqueous decoctions provided higher extraction yields. P. caramanicus exhibited strong ABTS radical scavenging activity.
Burak Bayrak, Ferhat Güneş, Beyzanur Akyüz, Elif Beyza Özer, Amenah Imad Abdulqader, Ayşe Çivaş, İsranur Küçüksu, Hatice Rümeysa Sönmez, Ömer Çeçen, Bilge Aydın, Furkan Çoban, Hafize Yuca, Songül Karakaya   +12 more
wiley   +1 more source

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Molecules, 2017
Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the ...
Yang Gao, Liyi Geng, Vicky Ping Chen, Stephen Brimijoin   +3 more
doaj   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source

DEVELOPMENT OF BUTYRYLCHOLINESTERASE LIGANDS FOR THE IMAGING OF NEUROLOGICAL DISORDERS

, 2013
Butyrylcholinesterase (BuChE) is a serine hydrolase enzyme that, along with acetylcholinesterase (AChE), catalyzes the hydrolysis of acetylcholine. These enzymes are associated with the pathology of neurologic disorders such as Alzheimer's disease (AD)
Macdonald, Ian
core  

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

Chemistry
Cholinesterases are enzymes that break down the neurotransmitter acetylcholine in the nervous system. The two main types are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE inhibitors are used to treat Alzheimer’s disease by increasing
Evdokiya Salamanova, Mariyana Atanasova, Irini Doytchinova   +2 more
doaj   +1 more source