Results 61 to 70 of about 14,314 (224)

Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

Biomolecules, 2020
Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids of belladine structural type, named carltonine A-C (13–15), were isolated from bulbs of Narcissus pseudonarcissus cv.
Abdullah Al Mamun, Jana Maříková, Daniela Hulcová, Jiří Janoušek, Marcela Šafratová, Lucie Nováková, Tomáš Kučera, Martina Hrabinová, Jiří Kuneš, Jan Korábečný, Lucie Cahlíková   +10 more
doaj   +1 more source

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Molecular forms of butyrylcholinesterase and obesity [PDF]

Genetics and Molecular Biology, 2010
This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE ...
Boberg, Dellyana R., Furtado-Alle, Lupe, Souza, Ricardo L.R., Chautard-Freire-Maia, Eleidi A.   +3 more
openaire   +5 more sources

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease

Molecules, 2018
Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic
Weiam Hussein, Begüm Nurpelin Sağlık, Serkan Levent, Büşra Korkut, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı   +6 more
doaj   +1 more source

Comparison of biochemical, haematological and plasmatic butyrylcholinesterase parameters in farmers and non-farmers, Morocco

Advanced Biomedical Research, 2023
Background: The long-term use of pesticides can cause harmful consequences to both human health and the environment. In the present research, we aimed to compare biochemical, hematological, and plasmatic measurements of butyrylcholinesterase (BChE ...
Hasnaa Sine, Youssef Bouchriti, Hayat Sine, Abderrahmane Achbani   +3 more
doaj   +1 more source

Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment

, 2005
The most successful approach for treating people with Alzheimer's disease to date has been by improving cholinergic transmission using cholinesterase inhibitors.
Elaine K Perry, Ballard, C G, Clive G Ballard, Tasker, A, Andrea Tasker, Perry, E K   +5 more
core   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

The biological activities of butyrylcholinesterase inhibitors

Biomedicine & Pharmacotherapy, 2022
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term treatment effect. Recent studies have shown that butyrylcholinesterase (BuChE) inhibitors or double acetyl and butyryl cholinesterase inhibitors have better curative ...
Shiyang, Zhou, Gangliang, Huang
openaire   +2 more sources

Synthesis, Structural Characterization, and Cholinesterase Inhibition of Sulfonamide Derivatives Incorporating Dipeptide Units

Journal of Chemistry
Five new sulfonamide deriatives bearing dipeptide moieties (4a-e) were synthesized and assessed for their inhibitory activity against acetylcholinesterase and butyrylcholinesterase. First, the condensation reaction of benzenesulfonyl chlorides (1a-c) and
Florence Uchenna Eze, Joshua Tochukwu Okoro, James Anayochukwu Ezugwu, Ogechi Chinelo Ekoh, Jeanet Conradie, David Izuchukwu Ugwu   +5 more
doaj   +1 more source

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase

Frontiers in Pharmacology, 2018
Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters.
Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P. Chen   +3 more
doaj   +1 more source