Results 61 to 70 of about 14,374 (222)

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase

Frontiers in Pharmacology, 2018
Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters.
Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P. Chen   +3 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Emerging significance of butyrylcholinesterase

World Journal of Experimental Medicine
Butyrylcholinesterase (BChE; EC 3.1.1.8), an enzyme structurally related to acetylcholinesterase, is widely distributed in the human body. It plays a role in the detoxification of chemicals such as succinylcholine, a muscle relaxant used in anesthetic practice.
Sridhar, Gumpeny R, Gumpeny, Lakshmi
openaire   +2 more sources

The biological activities of butyrylcholinesterase inhibitors

Biomedicine & Pharmacotherapy, 2022
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term treatment effect. Recent studies have shown that butyrylcholinesterase (BuChE) inhibitors or double acetyl and butyryl cholinesterase inhibitors have better curative ...
Shiyang, Zhou, Gangliang, Huang
openaire   +2 more sources

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Synthesis, Structural Characterization, and Cholinesterase Inhibition of Sulfonamide Derivatives Incorporating Dipeptide Units

Journal of Chemistry
Five new sulfonamide deriatives bearing dipeptide moieties (4a-e) were synthesized and assessed for their inhibitory activity against acetylcholinesterase and butyrylcholinesterase. First, the condensation reaction of benzenesulfonyl chlorides (1a-c) and
Florence Uchenna Eze, Joshua Tochukwu Okoro, James Anayochukwu Ezugwu, Ogechi Chinelo Ekoh, Jeanet Conradie, David Izuchukwu Ugwu   +5 more
doaj   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

The Proline-Rich Tetramerization Peptides In Equine Serum Butyrylcholinesterase [PDF]

, 2012
Soluble, tetrameric, plasma butyrylcholinesterase from horse has previously been shown to include a non-covalently attached polyproline peptide in its structure. The polyproline peptide matched the polyproline-rich region of human lamellipodin.
Biberoglu, Kevser, Lockridge, Oksana, Schopfer, Lawrence M., Tacal, Ozden   +3 more
core   +1 more source

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

Molecules, 2020
Bacterial transglutaminase was used to label human plasma proteins with fluorescent tags. Protein lysines were modified with dansyl-epsilon-aminohexyl-Gln-Gln-Ile-Val-OH (dansylQQIV), while protein glutamines were modified with dansyl cadaverine. Labeled
Lawrence M. Schopfer, Oksana Lockridge
doaj   +1 more source

Comparison of biochemical, haematological and plasmatic butyrylcholinesterase parameters in farmers and non-farmers, Morocco

Advanced Biomedical Research, 2023
Background: The long-term use of pesticides can cause harmful consequences to both human health and the environment. In the present research, we aimed to compare biochemical, hematological, and plasmatic measurements of butyrylcholinesterase (BChE ...
Hasnaa Sine, Youssef Bouchriti, Hayat Sine, Abderrahmane Achbani   +3 more
doaj   +1 more source