Results 21 to 30 of about 85,087 (299)

AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study

BMC Anesthesiology, 2020
Background Up to 70% of septic patients develop a diffuse brain dysfunction named “septic associated encephalopathy” which is often solely based on clinical impressions.
Benedikt Zujalovic, Benjamin Mayer, Sebastian Hafner, Florian Balling, Eberhard Barth   +4 more
doaj   +1 more source

Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors [PDF]

, 2019
A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors.
Zhu, Zheying, Yao, Hequan, Xu, Feijie, Yang, Limei, Li, Wenlong, Yin, Ying, Shuai, Wen, Xu, Shengtao, Xu, Jinyi   +8 more
core   +1 more source

A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard   +20 more
doaj   +1 more source

Biochemical and molecular responses of the freshwater snail Pila sp. to environmental pollutants, abiotic, and biotic stressors

Frontiers in Environmental Science, 2022
The semi-sessile, ectothermic, amphibious mollusc Pila globosa receives less attention for studying its environmental aspects. Its ecological role, ecotoxic and physiological responses to environmental factors including pollution and during dormant ...
Falguni Panda, Falguni Panda, Samar Gourav Pati, Samar Gourav Pati, Kajari Das, Luna Samanta, Dipak Kumar Sahoo, Biswaranjan Paital   +7 more
doaj   +1 more source

Biological activities of ethanolic extracts from deep-sea antarctic marine sponges [PDF]

, 2013
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth ...
Jerneja Avguštin, Jerneja Ambrožič Avguštin, Dorte Janussen, Ambrožič Avguštin, Jerneja, Strugar, Gašper, Silke Kauferstein, Tom Turk, Mebs, Dietrich, Dietrich Mebs, Turk, Tom, Kauferstein, Silke, Rok Kosmina, Gašper Strugar, Čivović, Sandra, Janussen, Dorte, Urška Batista, Kristina Sepčić, Sandra Čivović, Kosmina, Rok, Batista, Urška, Sepčić, Kristina   +20 more
core   +1 more source

A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection

Frontiers in Immunology, 2023
Schistosomes are long-lived parasitic worms that infect >200 million people globally. The intravascular life stages are known to display acetylcholinesterase (AChE) activity internally as well as, somewhat surprisingly, on external tegumental ...
Patrick J. Skelly, Akram A. Da’dara
doaj   +1 more source

Variation in Drosophila acetylcholinesterase

Biochemical Genetics, 1980
Uploaded by Plazi for TaxoDros. We do not have abstracts.
R A, Morton, R S, Singh
openaire   +2 more sources

Involvement of acetylcholinesterase inhibition in paralyzing effects of monocrotophos in Caenorhabditis elegans

Journal of Basic and Applied Zoology, 2018
Background Organophosphorus insecticides (OPI) are among the most commonly used class of pesticides in agricultural and domestic scenarios. Clinical presentations of acute OPI toxicity are attributable to acetylcholinesterase inhibition and ensuing ...
Apurva Kumar Ramesh Joshi, Raju Nagaraju, Padmanabhan Sharda Rajini   +2 more
doaj   +1 more source

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +1 more source

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]

, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Tikva Vogel, Kreuter, Jörg (Prof. Dr.), Sascha Wien, Zensi, Anja, Kufleitner, Jürgen, Jörg Kreuter, Wien, Sascha, Jürgen Kufleitner, Bungert, Judith, Wagner, Sylvia, Judith Bungert, Dadparvar, Miriam, Vogel, Tikva, Anja Zensi, Sylvia Wagner, Worek, Franz, Miriam Dadparvar, Hagen von Briesen, Briesen, Hagen von, Franz Worek   +19 more
core   +2 more sources