Results 21 to 30 of about 176,476 (335)

Structure-Based Design and Molecular Dynamics Simulations of Pentapeptide AEYTR as a Potential Acetylcholinesterase Inhibitor

Indonesian Journal of Chemistry, 2020
Structure-based virtual screening protocol to identify potent acetylcholinesterase inhibitors was retrospectively validated. The protocol could be employed to examine the potential of designed compounds as novel acetylcholinesterase inhibitors.
Vivitri Dewi Prasasty, Enade Perdana Istyastono   +1 more
doaj   +1 more source

Bacopa monnieri: A promising herbal approach for neurodegenerative disease treatment supported by in silico and in vitro research

Heliyon, 2023
Neurodegenerative disorders, caused by progressive neuron loss, are a global health issue. Among the various factors implicated in their pathogenesis, dysregulation of acetylcholinesterase activity has been recognized as a key contributor ...
Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A. Attia, Asmaa M. Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Ali   +8 more
doaj   +1 more source

Exploring Concomitant Acetylcholinesterase Inhibitor and Overactive Bladder Anticholinergic Use and Risk of Hospitalization in Medicare and Dual-Eligible Medicare–Medicaid Populations in a Historic Database

Pharmacy, 2023
Overactive bladder prevalence increases in older adults often complicating the management of other comorbidities. The theoretical antagonism between the parasympathetic-blocking anticholinergic agent and the parasympathetic stimulatory agents ...
Jonathan H. Watanabe, Tu Hoang
doaj   +1 more source

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

Distribution of chromaffin secretory vesicles, acetylcholinesterase, and lysosomal enzymes in sucrose and percoll gradients [PDF]

, 1984
Crude chromaffin secretory vesicles, obtained by differential centrifugation, were further purified on isotonic (Percoll) gradients. The chromaffin vesicle fractions recovered from the gradients contain acetylcholinesterase as well as lysosomal enzymes ...
Bowers, Carty, Cheng, Cheng, Chubb, Farquhar, Gratzi, Gratzl, Gratzl, Hall, Hasilik, Jørgensen, Krieger-Brauer, Krieger-Brauer, Krieger-Brauer, Little, Manfred Gratzl, Meisler, Mizobe, Mizobe, Saermark, Saermark, Saermark, Saermark, Schneider, Schneider, Schneider, Silsand, Smith, Terland, Wilson, Zinder   +31 more
core   +1 more source

Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors

Acta Medica, 2015
Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for
Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohanka   +2 more
doaj   +1 more source

New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation [PDF]

, 2016
A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE).
Chiarotto, Isabella, Costi, Roberta, DE VITA, Daniela, DI SANTO, Roberto, Feroci, Marta, Ornano, Luigi, Pandolfi, Fabiana, Pepi, Federico, Scipione, Luigi, Sileno, Ilaria   +9 more
core   +1 more source

Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: Implication in peripheral inflammation [PDF]

, 2018
Multiple Sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, and both genetic and environmental factors contribute to the pathogenesis of the disease.
Costantini, Erica, D'Angelo, Chiara, D'Aurora, Marco, Di Bari, Maria, Di Nicola, Marta, Franchi, Sara, Galizia, Sabrina, Gasperini, Claudio, Gatta, Valentina, Orlando, Viviana, Reale, Marcella, Ruggieri, Serena, Stuppia, Liborio, Tata, Ada Maria   +13 more
core   +3 more sources

Acetylcholinesterase, Specific Acetylcholinesterase and Total Protein Concentrations in the Brain Regions of Broiler Chickens Fed Dietary Monosodium Glutamate

Turkish Journal of Agriculture: Food Science and Technology, 2019
The study was carried out to examine the effect of varied levels of dietary monosodium glutamate on acetylcholinesterase, specific acetylcholinesterase and total protein concentrations in the brain regions of broiler chickens.
Olumuyiwa Joseph Olarotimi, Imoleayo Sarah Oladeji, Olufemi Adesanya Adu, Francis Ayodeji Gbore   +3 more
doaj   +1 more source

The influence of in vitro gastrointestinal digestion on the chemical composition and antioxidant and enzyme inhibitory capacities of carob liqueurs obtained with different elaboration techniques [PDF]

, 2019
Carob liqueur is a traditional Mediterranean alcoholic beverage obtained via a wide range of production techniques contributing to the different organoleptic attributes of the final product.
Coelho, Natacha, Gonçalves, Sandra, Pérez-Santín, Efrén, Rodríguez Solana, Raquel, Romano, Anabela, Santos-Rufo, Antonio   +5 more
core   +1 more source