Results 21 to 30 of about 51,436 (262)

The Effect of Parathion on Red Blood Cell Acetylcholinesterase in the Wistar Rat

Journal of Toxicology, 2016
Organophosphorus (OP) pesticide poisoning is a significant problem worldwide. Research into new antidotes for these acetylcholinesterase inhibitors, and even optimal doses for current therapies, is hindered by a lack of standardized animal models.
Naofumi Bunya, Keigo Sawamoto, Hanif Benoit, Steven B. Bird   +3 more
doaj   +1 more source

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice

Frontiers in Molecular Neuroscience, 2012
The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant, Liliya eTamayev, Lili eAnglister   +2 more
doaj   +1 more source

Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention

Biomolecules, 2020
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare ...
Samir F. de A. Cavalcante, Alessandro B. C. Simas, Marcos C. Barcellos, Victor G. M. de Oliveira, Roberto B. Sousa, Paulo A. de M. Cabral, Kamil Kuča, Tanos C. C. França   +7 more
doaj   +1 more source

Insecticidal Terpenes From the Essential Oils of Artemisia nakaii and Their Inhibitory Effects on Acetylcholinesterase

Frontiers in Plant Science, 2021
Essential oils (EOs) are often the source of insecticidal substances of high efficiency and low toxicity. From gas chromatograph-mass spectrometer, column chromatography, and nuclear magnetic resonance spectra analyses, twenty terpenes were identified ...
Jiayi Liu, Juan Hua, Juan Hua, Bo Qu, Bo Qu, Xuanyue Guo, Yangyang Wang, Meini Shao, Shihong Luo, Shihong Luo   +9 more
doaj   +1 more source

Organophosphorus insecticides: Toxic effects and bioanalytical tests for evaluating toxicity during degradation processes [PDF]

Hemijska Industrija, 2013
Organophosphorus insecticides have been the most applied group of insecticides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE).
Čolović Mirjana B., Krstić Danijela Z., Vasić Vesna M., Bondžić Aleksandra M., Ušćumlić Gordana S., Petrović Slobodan D.   +5 more
doaj   +1 more source

ACETYLCHOLINESTERASE, TYROSINASE AND PEROXIREDOXIN ENZYME INHIBITORY ACTIVITY STUDIES OF SYNTHESISED OXADIAZOLES AND THIADIAZOLES FROM SCHIFF BASES [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
With the increasing prevalence of neurodegenerative diseases (NDDs) and the limited effectiveness of existing treatments, there is a pressing need to discover new therapeutic leads that can interact with multiple targets implicated in NDD pathogenesis. A
Sindhu J, JAINEY JAMES, keerthan shettigar, Zakiya C   +3 more
doaj   +1 more source

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Molecules, 2018
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green, Marina Y. Fosso, Sylvie Garneau-Tsodikova   +2 more
doaj   +1 more source

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations

Royal Society Open Science
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the ...
Quynh Mai Thai, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ngo   +4 more
doaj   +1 more source

An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet

Molecules, 2017
Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for treatment of various cholinergic deficiencies, including Alzheimer’s ...
Anders Allgardsson, C. David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekström   +5 more
doaj   +1 more source

Artemisia santonicum L. and Artemisia lerchiana Web. Essential Oils and Exudates as Sources of Compounds with Pesticidal Action

Plants, 2023
The application of natural products for pest control is important in modern farming. In the present study, Artemisia santonicum L. and Artemisia lerchiana Weber essential oil and exudate profiles were determined, and their potential as inhibitors of seed
Milena Nikolova, Aneta Lyubenova, Elina Yankova-Tsvetkova, Borislav Georgiev, Strahil Berkov, Ina Aneva, Antoaneta Trendafilova   +6 more
doaj   +1 more source