Results 31 to 40 of about 178,300 (339)

A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard   +20 more
doaj   +1 more source

Biochemical and molecular responses of the freshwater snail Pila sp. to environmental pollutants, abiotic, and biotic stressors

Frontiers in Environmental Science, 2022
The semi-sessile, ectothermic, amphibious mollusc Pila globosa receives less attention for studying its environmental aspects. Its ecological role, ecotoxic and physiological responses to environmental factors including pollution and during dormant ...
Falguni Panda, Falguni Panda, Samar Gourav Pati, Samar Gourav Pati, Kajari Das, Luna Samanta, Dipak Kumar Sahoo, Biswaranjan Paital   +7 more
doaj   +1 more source

Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water [PDF]

, 2017
The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport ...
A. G. Becker, ALMROTH B.C., AZAMBUJA C.R., B. Baldisserotto, B. M. Heinzmann, BALDISSEROTTO B., BECKER A.G., BECKER A.G., BENOVIT S.C., BLENAU W., BRADFORD M.M., BUEGE J.A., C. C. Menezes, C. C. Zeppenfeld, C. Toni, COOKE S.J., CUNHA M.A., CUNHA M.A., DUBOIS M., ELLMAN G.L., ELLMAN G.L., GONÇALVES A.F.N., GOYAL A.K., HABIG W.H., HARROWER J.R., HUDETZ A.G., INOUE L.A.K.A., INOUE L.A.K.A., J. Salbego, LEUNG L.S., LINTERN M.C., LOWRY O.H., LÓPEZ M.D., MATÉS J.M., MAZZANTI L., MOMMSEN T.P., PANKHURST N.W., PARODI T.V., ROSS L.G., ROUBACH R., SALBEGO J., SALBEGO J., TONI C., UNGVARI Z., V. L. Loro, VALE T.G., VALE T.G., VILLARES JUNIOR G.A., YAN L.J., YONAR M.E., ZAHL I.H.   +50 more
core   +2 more sources

Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy

Frontiers in Pharmacology, 2018
Alzheimer's disease (AD) is a main cause of dementia, accounting for up to 75% of all dementia cases. Pathophysiological processes described for AD progression involve neurons and synapses degeneration, mainly characterized by cholinergic impairment ...
Thaiane Coelho dos Santos, Thaís Mota Gomes, B. A. S. Pinto, A. L. Camara, A. M. Paes   +4 more
semanticscholar   +1 more source

Involvement of acetylcholinesterase inhibition in paralyzing effects of monocrotophos in Caenorhabditis elegans

Journal of Basic and Applied Zoology, 2018
Background Organophosphorus insecticides (OPI) are among the most commonly used class of pesticides in agricultural and domestic scenarios. Clinical presentations of acute OPI toxicity are attributable to acetylcholinesterase inhibition and ensuing ...
Apurva Kumar Ramesh Joshi, Raju Nagaraju, Padmanabhan Sharda Rajini   +2 more
doaj   +1 more source

A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection

Frontiers in Immunology, 2023
Schistosomes are long-lived parasitic worms that infect >200 million people globally. The intravascular life stages are known to display acetylcholinesterase (AChE) activity internally as well as, somewhat surprisingly, on external tegumental ...
Patrick J. Skelly, Akram A. Da’dara
doaj   +1 more source

Variation in Drosophila acetylcholinesterase

Biochemical Genetics, 1980
Uploaded by Plazi for TaxoDros. We do not have abstracts.
R A, Morton, R S, Singh
openaire   +2 more sources

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors.

Bioorganic chemistry (Print), 2019
A series of substituted pyrazole compounds (1-8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1-8 and 9a, b) were emerged as effective inhibitors of the ...
Fikret Turkan, A. Cetin, Parham Taslimi, M. Karaman, I. Gulcin   +4 more
semanticscholar   +1 more source

Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]

, 2015
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa, Florêncio Nogueira, Fouzi Mouffouk, Hugo Pereira, José Manuel, João Varela, Khalid M. Abu-salah, Luísa Barreira, Luísa Custódio, Maria João Rodrigues, Marta Oliveira, Nuno Da Rosa Neng, Radhouan Ben-hamadou, Salman A. Alrokayan, The Red Sea   +14 more
core   +4 more sources

Nootropics use in the workplace. Psychiatric and ethical aftermath towards the new frontier of bioengineering [PDF]

, 2020
OBJECTIVE: The authors have sought to expound upon and shed a light on the rise of nootropics, which have gradually taken on a more and more relevant role in workplaces and academic settings.
Bersani, G, Ciallella, C, Del Rio, A, Marinelli, E, Rinaldi, Raffaella, Zaami, S   +5 more
core   +1 more source