Results 11 to 20 of about 85,087 (299)

Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors

Acta Medica, 2015
Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for
Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohanka   +2 more
doaj   +2 more sources

Amperometric acetylcholinesterase biosensor for physostigmine determination

Учёные записки Казанского университета: Серия Естественные науки, 2018
A biosensor based on acetylcholinesterase immobilized by carbodiimide binding on glassy carbon electrode modified with carbon black and Co(II) phthalocyanine has been developed.
R.R. Davletshina, A.N. Ivanov, G.A. Evtugyn   +2 more
doaj   +1 more source

Exploring Concomitant Acetylcholinesterase Inhibitor and Overactive Bladder Anticholinergic Use and Risk of Hospitalization in Medicare and Dual-Eligible Medicare–Medicaid Populations in a Historic Database

Pharmacy, 2023
Overactive bladder prevalence increases in older adults often complicating the management of other comorbidities. The theoretical antagonism between the parasympathetic-blocking anticholinergic agent and the parasympathetic stimulatory agents ...
Jonathan H. Watanabe, Tu Hoang
doaj   +1 more source

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
core   +2 more sources

New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]

, 2000
Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier   +9 more
core   +1 more source

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease [PDF]

, 1999
Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Görbig, Diana Marina, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier, Xavier Barril, Francisco Javier Luque, Nuria María Vivas, Pelayo Camps, Jordi Morral, Modesto Orozco, Diana Marina Görbig, Albert Badia, Rachid El Achab, Josep Eladi Baños, Diego Muñoz-Torrero   +21 more
core   +1 more source

Protection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase

Scientific Reports, 2022
Cytokine receptor-like factor 3 (CRLF3) is a conserved but largely uncharacterized orphan cytokine receptor of eumetazoan animals. CRLF3-mediated neuroprotection in insects can be stimulated with human erythropoietin.
Debbra Y. Knorr, Kristin Schneider, Luca Büschgens, Jan Förster, Nadine S. Georges, Bart R. H. Geurten, Ralf Heinrich   +6 more
doaj   +1 more source

ANTIBODIES TO ACETYLCHOLINESTERASE [PDF]

Proceedings of the National Academy of Sciences, 1969
A rabbit antiserum against commercially available Electrophorus electricus acetylcholinesterase has been prepared. Five precipitation bands were distinguished by immunoelectrophoresis, but only three of these contained demonstrable enzyme activity. In an in vitro
openaire   +2 more sources

Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation [PDF]

, 2014
Cholinesterase inhibitors (ChE-Is) are the standard for the therapy of AD associated disorders and are the only class of approved drugs by the Food and Drug Administration (FDA).
Kuldeep Uchadia, Uchadia, Kuldeep, Chandrabhan Seniya, Ghulam Jilani Khan, Seniya, Chandrabhan, Khan, Ghulam Jilani   +5 more
core   +1 more source