Results 11 to 20 of about 75,116 (210)

Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors

Acta Medica, 2015
Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for
Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohanka   +2 more
doaj   +2 more sources

Acetylcholinesterase, Specific Acetylcholinesterase and Total Protein Concentrations in the Brain Regions of Broiler Chickens Fed Dietary Monosodium Glutamate

Turkish Journal of Agriculture: Food Science and Technology, 2019
The study was carried out to examine the effect of varied levels of dietary monosodium glutamate on acetylcholinesterase, specific acetylcholinesterase and total protein concentrations in the brain regions of broiler chickens.
Olumuyiwa Joseph Olarotimi, Imoleayo Sarah Oladeji, Olufemi Adesanya Adu, Francis Ayodeji Gbore   +3 more
doaj   +3 more sources

Amperometric acetylcholinesterase biosensor for physostigmine determination

Учёные записки Казанского университета: Серия Естественные науки, 2018
A biosensor based on acetylcholinesterase immobilized by carbodiimide binding on glassy carbon electrode modified with carbon black and Co(II) phthalocyanine has been developed.
R.R. Davletshina, A.N. Ivanov, G.A. Evtugyn   +2 more
doaj   +1 more source

Exploring Concomitant Acetylcholinesterase Inhibitor and Overactive Bladder Anticholinergic Use and Risk of Hospitalization in Medicare and Dual-Eligible Medicare–Medicaid Populations in a Historic Database

Pharmacy, 2023
Overactive bladder prevalence increases in older adults often complicating the management of other comorbidities. The theoretical antagonism between the parasympathetic-blocking anticholinergic agent and the parasympathetic stimulatory agents ...
Jonathan H. Watanabe, Tu Hoang
doaj   +1 more source

New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]

, 2000
Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier   +9 more
core   +1 more source

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease [PDF]

, 1999
Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Görbig, Diana Marina, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier   +10 more
core   +1 more source

ANTIBODIES TO ACETYLCHOLINESTERASE [PDF]

Proceedings of the National Academy of Sciences, 1969
A rabbit antiserum against commercially available Electrophorus electricus acetylcholinesterase has been prepared. Five precipitation bands were distinguished by immunoelectrophoresis, but only three of these contained demonstrable enzyme activity.
openaire   +2 more sources

Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation [PDF]

, 2014
Cholinesterase inhibitors (ChE-Is) are the standard for the therapy of AD associated disorders and are the only class of approved drugs by the Food and Drug Administration (FDA).
Kuldeep Uchadia, Uchadia, Kuldeep, Chandrabhan Seniya, Ghulam Jilani Khan, Seniya, Chandrabhan, Khan, Ghulam Jilani   +5 more
core   +1 more source

A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard   +20 more
doaj   +1 more source

Biochemical and molecular responses of the freshwater snail Pila sp. to environmental pollutants, abiotic, and biotic stressors

Frontiers in Environmental Science, 2022
The semi-sessile, ectothermic, amphibious mollusc Pila globosa receives less attention for studying its environmental aspects. Its ecological role, ecotoxic and physiological responses to environmental factors including pollution and during dormant ...
Falguni Panda, Falguni Panda, Samar Gourav Pati, Samar Gourav Pati, Kajari Das, Luna Samanta, Dipak Kumar Sahoo, Biswaranjan Paital   +7 more
doaj   +1 more source