Results 301 to 310 of about 124,541 (336)

Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors

Archiv der Pharmazie, 2021
To develop new acetylcholinesterase (AChE)–monoamine oxidase‐B (MAO‐B) dual inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO‐B inhibitory activity, was used as the main ...
Derya Osmaniye, A. Evren, B. Sağlık, Serkan Levent, Y. Özkay, Z. Kaplancıklı   +5 more
semanticscholar   +1 more source

Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors.

Food & Function, 2020
Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE 1) play vital roles in the development and progression of Alzheimer's disease (AD). The objective of the present study was to identify fish roe-derived anti-AD peptides
Zhipeng Yu, Huizhuo Ji, J. Shen, R. Kan, Wenzhu Zhao, Jianrong Li, Long Ding, Jingbo Liu   +7 more
semanticscholar   +1 more source

Acetylcholinesterase Enzyme (AChE) as a Biosensor and Biomarker for Pesticides: A Mini Review

Bulletin of Environmental Science and Sustainable Management (e-ISSN 2716-5353), 2020
Due to the increase in pesticide usage the cost of food production has been drastically reduced worldwide. There are dangers related to the ever-increasing pesticide application especially to the non-target biota and to also to the environment at large ...
A. M. Umar, Abubakar Aisami
semanticscholar   +1 more source

Near-Infrared Fluorescence Probe for Evaluating Acetylcholinesterase (AChE) Activity in PC12 Cells and In Situ Tracing AChE Distribution in Zebrafish.

ACS Sensors, 2019
Acetylcholinesterase (AChE) plays crucial roles in numerous physiological processes such as cell differentiation, cell apoptosis, and nerve tissues development.
Jianlong Ma, Tiantian Si, Chaoxian Yan, Yijing Li, Qiang Li, Xiaofeng Lu, Yong Guo   +6 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease.

ACS Chemical Neuroscience, 2018
A series of dual-target AChE/PDE9A inhibitor compounds were designed, synthesized, and evaluated as anti-Alzheimer's Disease (AD) agents. Among these target compounds, 11a (AChE: IC50 = 0.048 μM; PDE9A: IC50 = 0.530 μM) and 11b (AChE: IC50 = 0.223 μM ...
Jinhui Hu, Yadan Huang, Tingting Pan, Tianhua Zhang, Tao Su, Xingshu Li, Hai-bin Luo, Ling Huang   +7 more
semanticscholar   +1 more source

Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish.

Methods in molecular biology, 2021
C. Gravato, F. Abe, D. P. de Oliveira, A. Soares, Inês Domingues   +4 more
semanticscholar   +1 more source

Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors

Chemické zvesti, 2019
M. Işık, Yeliz Demir, M. Durgun, Cüneyt Türkeş, Adem Necip, Ş. Beydemir   +5 more
semanticscholar   +1 more source

The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking

Neurochemical Research, 2019
M. Işık
semanticscholar   +1 more source

Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress

Metabolic brain disease, 2018
Kaiyue Sun, Yuting Bai, Rong Zhao, Zijiao Guo, Xiang Su, Peiqi Li, Pengyu Yang   +6 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

ACS Chemical Neuroscience, 2017
Fei Mao, Huan Wang, Wei Ni, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang, Jian Li   +10 more
semanticscholar   +1 more source