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Achalasia [PDF]

Nature Reviews Disease Primers, 2022
Achalasia is characterized by peristaltic failure and incomplete relaxation of the lower esophageal sphincter. The incidence and prevalence of achalasia increase with age, although achalasia can affect all age groups.
Edoardo Savarino, Shobna Bhatia, Sabine Roman   +2 more
exaly   +2 more sources

Role of endoscopy in patients with achalasia [PDF]

Clinical Endoscopy, 2023
Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter relaxation and peristalsis of the esophageal body.
So Young Han, Young Hoon Youn
doaj   +1 more source

Psychological burden of achalasia: Patients' screening rates of depression and anxiety and sex differences.

PLoS ONE, 2023
ObjectiveAchalasia is associated with reduced quality of life in affected patients but research regarding the psychological burden of achalasia in terms of depression and anxiety is scarce.
Franz Hanschmidt, Julia Treml, Julia Deller, Nicole Kreuser, Ines Gockel, Anette Kersting   +5 more
doaj   +1 more source

Achalasia is associated with a higher incidence of depression in outpatients in Germany.

PLoS ONE, 2021
Background and aimAchalasia represents a chronic motility disorder of the esophagus featuring an impaired lower esophageal sphincter relaxation and loss of esophageal peristalsis.
Sven H Loosen, Jennis Kandler, Tom Luedde, Karel Kostev, Christoph Roderburg   +4 more
doaj   +1 more source

RNA-sequencing reveals molecular and regional differences in the esophageal mucosa of achalasia patients

Scientific Reports, 2022
Achalasia is an esophageal motility disorder characterized by the functional loss of myenteric plexus ganglion cells in the distal esophagus and lower esophageal sphincter.
Caroline K. Patel, Peter J. Kahrilas, Nathan B. Hodge, Lia E. Tsikretsis, Dustin A. Carlson, John E. Pandolfino, Marie-Pier Tétreault   +6 more
doaj   +1 more source

Primary versus secondary achalasia: New signs on barium esophagogram

Indian Journal of Radiology and Imaging, 2015
Aim: To investigate new signs on barium swallow that can differentiate primary from secondary achalasia. Materials and Methods: Records of 30 patients with primary achalasia and 17 patients with secondary achalasia were reviewed.
Pankaj Gupta, Uma Debi, Saroj Kant Sinha, Kaushal Kishor Prasad   +3 more
doaj   +1 more source

A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

Nature Communications, 2023
Achalasia is a rare motility disorder of the esophagus caused by the gradual degeneration of myenteric neurons. Immune-mediated ganglionitis has been proposed to underlie the loss of myenteric neurons.
Zu-Qiang Liu, Hao Dai, Lu Yao, Wei-Feng Chen, Yun Wang, Li-Yun Ma, Xiao-Qing Li, Sheng-Li Lin, Meng-Jiang He, Ping-Ting Gao, Xin-Yang Liu, Jia-Xin Xu, Xiao-Yue Xu, Ke-Hao Wang, Li Wang, Luonan Chen, Ping-Hong Zhou, Quan-Lin Li   +17 more
doaj   +1 more source

High-resolution manometric features of achalasia of the cardia

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Achalasia of the cardia is a common esophageal motility disorder. High-resolution manometry is the gold standard for the diagnosis of achalasia.
Deepanjan Dey, Karuna Datta, DK Dubey, Deep Sharma   +3 more
doaj   +1 more source

Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients

Case Reports in Gastrointestinal Medicine, 2016
The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE/achalasia without treatment versus achalasia group. In
Samuel Torres-Landa, Janette Furuzawa-Carballeda, Enrique Coss-Adame, Miguel A. Valdovinos, Edgar Alejandro-Medrano, Bárbara Ramos-Ávalos, Braulio Martínez-Benítez, Gonzalo Torres-Villalobos   +7 more
doaj   +1 more source

Management of Achalasia: Expert Consensus Statements

The Korean Journal of Gastroenterology, 2019
Achalasia is a motility disorder of the esophagus characterized by absence of peristalsis and failure of relaxation of lower esophagus sphincter. The introduction of high resolution manometry (HRM) and per-oral endoscopic myotomy (POEM) has made a new ...
A Reum Choe, Hye-Kyung Jung
doaj   +1 more source