Results 121 to 130 of about 771,630 (262)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Teacher Incentives and Student Achievement: Evidence from New York City Public Schools [PDF]

open access: yes
Financial incentives for teachers to increase student performance is an increasingly popular education policy around the world. This paper describes a school-based randomized trial in over two-hundred New York City public schools designed to better ...
Roland G. Fryer
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Defining the Minimal Clinically Important Difference and Patient Acceptable Symptom State for Isolated Microfracture of the Knee at 5-Year Follow-up. [PDF]

open access: yesOrthop J Sports Med
Saad Berreta R   +11 more
europepmc   +1 more source

The Effects of Self-Assessment on Achievement in an Algebra I Classroom

open access: yes, 2005
Students in an Algebra I classroom were asked to self-assess their learning of concepts involving the real number system. A self-assessment tool, the Capacity Matrix, was designed to emulate Bloom's taxonomy and provide students with a means of ...
Starling, Tina Tedder
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Narrowing the achievement gap : what and how schools learn through involvement in the specialist schools achievement programme – Part 1

open access: yes, 2010
This report was commissioned by the Specialist Schools and Academies Trust (SSAT) to find out how schools used the Specialist Schools Achievement Programme (SSAP) to narrow the gap between the academic attainment and wider achievements of students from ...
Brunner, Richard   +2 more
core  

Achieving Change

open access: yesJournal of the American College of Cardiology, 2011
openaire   +2 more sources

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