ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Linking EFL psychological capital and EFL achievement: the chain mediating effect of academic boredom and behavioural engagement. [PDF]
BMC PsycholWu Y, Kang X, Li Y.
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Do increasing participation rates in early childhood education narrow the reading achievement gap between high- and low-SES primary school students? [PDF]
Large Scale Assess EducSteinmann I, Medgyesi M, Symeonaki M.
europepmc +1 more source
Improving the Student Motivation of Learning Achievements by Giving Positive Words (The Students of Al-Firdaus Boarding House, Jln Ringin Wok Pahlawan, Kyai Honggowongso, Tambak Aji Ngaliyan Semarang) [PDF]
, 2013 Kurnia Widodo
openalex
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Investigating the roles of academic emotions in the relationship between agentic engagement and EFL achievement among Chinese undergraduate students. [PDF]
Front PsycholHe H.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source