Results 41 to 50 of about 23,600 (287)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi   +5 more
wiley   +1 more source

Multilevel analysis of student and school level factors on students’ academic achievement [PDF]

open access: yesفصلنامه نوآوری‌های آموزشی, 2018
This study aimed to investigate the factors affecting the academic achievement of students at both school and student levels. Therefore, 600 high school students from 20 schools completed student efficacy scale of Jinks and Morgan's (1999) and personal ...
M. Mohamadi   +4 more
doaj   +2 more sources

The role of self- and social directed goals in a problem based, collaborative learning context

open access: yes, 2013
Students’ learning goals demonstrate much stronger variety than traditional goal orientation models for classroom learning assume, especially when the educational context allows so.
Volet, S.   +23 more
core   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

open access: yesAdvanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice   +2 more
wiley   +1 more source

The Effect of Achievement Goal Orientation on the Self-management of College Judo Athletes [PDF]

open access: yesThe Asian Journal of Kinesiology, 2018
OBJECTIVES Primary purpose of current research was to examine effect of goal orientation tendency on self control. METHODS Among 2018 college athlets of Korea Judo Association, participants were recruited through convinence sampling. Except for insincere
Sungbae Park
doaj   +1 more source

Research on relationship between achievement goal orientation and miners’ safety performance based on chain intermediary effect

open access: yesMeikuang Anquan, 2022
In order to study the relation between miners’ achievement goal orientation and safety performance, avoid unsafe behavior and improve miners’ safety performance, this paper uses the chain intermediary effect to study the early warning mechanism of ...
LI Bin, LI Jizu
doaj   +1 more source

Achievement motivation of adult learners in Hong Kong- An exploratory study [PDF]

open access: yes, 2007
This thesis is focused on the question of motivation among adult students and the ways in which it can be theorised and investigated. The idea was prompted by three areas of concern.
Lee, Eva Wai-Chi
core  

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

open access: yesAdvanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora   +4 more
wiley   +1 more source

Enhancing Strength and Electrical Conductivity in Al–Zr–Sc Conductor Alloys Through Sn and Sr Microalloying and Two‐Step Aging Treatment

open access: yesAdvanced Engineering Materials, EarlyView.
Trace additions of Sn and Sr combined with a two‐step aging treatment are shown to enhance the microstructure and performance of Al–Zr–Sc conductor alloys. Strength and electrical conductivity increase concurrently through accelerated precipitation of fine Al3(Sc, Zr) precipitates and improved dislocation resistance, offering a cost‐effective pathway ...
Quan Shao   +3 more
wiley   +1 more source

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