Results 51 to 60 of about 3,301,987 (315)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Teaching and Teacher Education : An International Journal of Research and Studies, 2019 We developed a brief questionnaire for teachers' achievement goal orientations that allows for an accurate assessment, while also being feasible for complex research designs.
S. Janke +3 more
semanticscholar +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions
Advanced Engineering Materials, EarlyView.This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice +2 more
wiley +1 more source
Causal Explanation of Job Engagement of Physical Education Teachers Based on Goal Orientation and Teaching Emotions [PDF]
پژوهش در نظامهای آموزشی, 2021 This study aimed to explain the teachers' job involvement based on goal orientations by the mediating role of teaching emotions. Using random sampling method, 228 females (135) and male (116) high school teachers were selected from areas of the Tabriz ...
Elaham Tabatabai adnan +3 more
doaj
Task and Ego Orientation in Sport Questionnaire: A Mokken Scale Analysis
SAGE Open, 2023 Athletes’ goal orientations have been associated with a wide array of sport-related behaviors, thoughts, and perceptions. The two main goal orientations defined in the achievement goal theory framework are task and ego orientations.
Bára Elísabet Dagsdóttir +3 more
doaj +1 more source
The Impact of Achievement Orientation on Goal Clarity
International Journal of Management, Knowledge and LearningPurpose: This study is to enrich the scientific paradigm in the field of Islamic education management, and to explore the effect of achievement-oriented leadership style on the goal clarity, particularly the study of organizational behavior. Study design/methodology/approach: This study employs a quantitative research approach using the survey method ...
Muhamad Taridi +2 more
openaire +2 more sources
Personality and Individual Differences, 2019 In this article, we propose a hierarchical model of human goal striving. This conceptual model is based in the assumption that broader life aspirations shape achievement goal orientations.
S. Janke, O. Dickhäuser
semanticscholar +1 more source
Rethinking motivation goals for adolescents: Beyond achievement goals [PDF]
, 2012 For the past two decades the prime focus of motivation research in adolescence has been concerned with achievement goals, namely mastery and performance goals.
Mansfield, C.
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