Results 131 to 140 of about 123,866 (247)

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Effects of fatigue are more pronounced on the uninjured side during single‐limb jumps 2 years after an acute Achilles tendon rupture

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 11, Page 4187-4194, November 2026.
Abstract Purpose Achilles tendon rupture (ATR) is a serious lower limb injury that may result in persistent deficits in strength and endurance of the calf muscles. Compensatory mechanisms at proximal joints are known, but the effects of fatigue are less studied.
Unnur Sædís Jónsdóttir, Roy Tranberg, Karin Grävare Silbernagel, Annelie Brorsson, Kristín Briem   +4 more
wiley   +1 more source

Clinical Outcome of Achilles Tendon Rupture Repaired by a Modified Minimally Invasive Percutaneous Suturing [PDF]

Xiaoyang Qi,1,* Danxia Zheng,2,* Zhijie Lei,3,* Jianglin Yu,3 Xusheng Qiu,1,3 Yixin Chen2 1Department of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People’
Qiu X, Lei Z, Qi X, Chen Y, Yu J, Zheng D   +5 more
core  

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Quantitative Sodium MRI of the Human Patellar Tendon

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
Sodium MRI and 1H T2* measurements of the patellar tendon were conducted in 20 healthy volunteers and seven tendinopathy patients at a clinical field strength. Significant differences between the two groups were observed with both parameters. This demonstrates the feasibility of using sodium MRI in the patellar tendon and the potential for early ...
Rika Möller, Julia Jurisic, Lukas R. Drewes, Alexandra Ljimani, Hans‐Jörg Wittsack, Armin M. Nagel, Gerald Antoch, Lena M. Wilms, Anja Müller‐Lutz, Benedikt Kamp   +9 more
wiley   +1 more source

Two Novel ACTC1 Variants Cause Arthrogryposis Multiplex Congenita

Clinical Genetics, Volume 110, Issue 5, Page 584-589, November 2026.
We report on two individuals with arthrogryposis multiplex congenita who were heterozygous for ACTC1 missense variants (NM_005159.5; c.325G>A, p.Glu109Lys and c.650A>C, p.Lys217Thr) and provide a characterization of these variants through in vitro studies.
Lauren Kerr, Pierre Moffatt, Lauren Hyer, Sarah Nossov, Noémi Dahan‐Oliel, Frank Rauch   +5 more
wiley   +1 more source

Dissecting the Metabolic Costs of Uphill and Downhill Walking

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 11, November 2026.
ABSTRACT Work‐ and collision‐based models of locomotion relate the body's mechanical work requirements to metabolic energy expenditure at a system level, but do not capture the underlying force and work demands of muscle that drive energy use. Energy is liberated as heat to activate muscle and maintain force production (“force‐related costs”) and as ...
Luke N. Jessup, Luke A. Kelly, Andrew G. Cresswell, Glen A. Lichtwark   +3 more
wiley   +1 more source

Comparison of Percutaneous Achilles Tendon Lengthening and Open Z-Plasty in Children with Idiopathic Achilles Tendon Contracture. [PDF]

J Clin Med
Morasiewicz P, Robinson A, Tomczyk Ł, Kazubski K, Laszkowska Morasiewicz M, Leyko P.   +5 more
europepmc   +1 more source

Effect of Metatarsophalangeal Joint Position on Maximal Voluntary Isometric Ankle Plantar‐Flexion Torque

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 11, November 2026.
ABSTRACT The joint position at which maximal torque is produced indicates the optimal position for agonist muscles to function. It is well‐documented that the maximal voluntary isometric contraction (MVIC) torque of ankle plantar‐flexion varies with knee and ankle joint positions.
Hiroto Shiotani, Katsuki Takahashi, Kosei Taniai, Hayato Tsuru, Yasuo Kawakami   +4 more
wiley   +1 more source

The Effect of Fosinopril on Achilles Tendon Healing in a Rat Model. [PDF]

Int J Mol Sci
Asar ŞC, Balık MS, Tümkaya L, Mercantepe T, Topçu A, Şahin R.   +5 more
europepmc   +1 more source