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Results 11 to 20 of about 60 (60)

Never Late: Cerebrotendinous Xanthomatosis and Improvements in Neurocognitive Functions in an Adult Patient on Chenodeoxycholic Acid Treatment

Clinical Genetics, EarlyView.
Cerebrotendinous xanthomatosis is due to biallelic pathogenic variants in CYP27A1. We report a new patient and his good neurocognitive outcome on the chenodeoxycholic acid treatment despite therapy starting at the age of 34 years. This highlights the importance of recognizing treatable inherited metabolic diseases at any age.
Randa Sultan +6 more
wiley +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley +1 more source

Magnetic resonance imaging for diagnosing and managing deep digital flexor tendinopathy in equine athletes: Insights, advances and future directions

Equine Veterinary Journal, EarlyView.
Abstract Deep digital flexor (DDF) tendinopathy is a significant cause of lameness and poor performance in equine athletes with substantial implications for their return to athletic performance. Magnetic resonance imaging (MRI) is increasingly integrated into the diagnostic workup of horses with foot pain and has revolutionised the diagnosis and ...
Alexandra Scharf +3 more
wiley +1 more source

Effectiveness of tele‐guidance for physiotherapy in older patients with type 2 diabetes: A randomized controlled trial

Journal of Diabetes Investigation, EarlyView.
Comparison of clinical indices before and after intervention in both groups. ABSTRACT Aims/Introduction Whether regular intervention via modern communication tools is effective in older patients with type 2 diabetes is unclear. We aimed to determine the effects of tele‐guidance for physiotherapy on muscle strength in such patients.
Hiroaki Kataoka +3 more
wiley +1 more source

Anatomical design and production of a novel three‐dimensional co‐culture system replicating the human flexor digitorum profundus enthesis

Journal of Anatomy, EarlyView.
Anatomical morphometrics have been used to design and manufacture models of the flexor digitorum profundus tendon to bone insertion in vitro. This innovative approach can be used to design models of other enthesis regions with anatomical and clinical applicability.
Jeremy W. Mortimer, Philippa A. Rust, Jennifer Z. Paxton +2 more
wiley +1 more source

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann +8 more
wiley +1 more source

Computed microtomographic imaging of revascularization during healing of Achilles tendon injury

Journal of Anatomy, EarlyView.
This study explores the role of vascularization in tendon healing by comparing physiological and pathological angiogenesis. Using micro‐CT imaging, we identified distinct changes in vascular organization following injury, highlighting the dynamic interplay between angiogenesis and tendon pathology.
Mert Ocak +6 more
wiley +1 more source

Intramuscular tendon length in agonist–antagonist myoneural interface components in transtibial amputation: An anatomic study

Journal of Anatomy, EarlyView.
Interestingly, this study shows that tendons spanned over 75% of the distal muscle belly in all muscles, crucial for the innovative tibiotalar agonist–antagonist myoneural interface (AMI) construction. AMI simulates natural muscle–tendon interaction in amputees, improving prosthetic control despite anatomical constraints.
Viktoria Witowski +13 more
wiley +1 more source

Acute Lateral Ankle Sprain Impairs Function and Strength Without Altering Muscle or Tendon Stiffness: A Controlled Observational Study

Orthopaedic Surgery, EarlyView.
This study used shear‐wave elastography to assess Achilles tendon and calf muscle stiffness following acute lateral ankle sprain (LAS). Despite the expected alterations due to injury and unloading, no significant stiffness changes were observed over 6 weeks. Findings suggest potential compensatory mechanisms preserving tissue mechanical properties post‐
Pedro Bainy Franz +8 more
wiley +1 more source

Effect of artificial gravity on calcaneal bone marrow adipose tissue and mineral content in female and male participants in 60 days of bed rest

Experimental Physiology, EarlyView.
Abstract Modulation of bone marrow adipose tissue (BMAT) with prolonged inactivity was reported in haemopoietic but not in non‐haemopoietic bones. This prospective randomized controlled trial submitted 16 men and 8 women to 60 days of 6° head‐down‐tilt bed rest.
Tammy Liu +5 more
wiley +1 more source