Results 61 to 70 of about 33,396 (255)

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Continuous Intravenous Infusion of Hepatocyte Growth Factor Promotes the Development of a Fibrolytic Phenotype in Hepatic Macrophages and Stellate Cells in a Rat Model of Bile Duct Ligation

Hepatology Research, EarlyView.
This study demonstrates that continuous intravenous infusion of hepatocyte growth factor can significantly reduce liver fibrosis in rats. This treatment promotes hepatocyte regeneration and reduces harmful inflammation, offering promising potential as a therapy for liver cirrhosis in humans. ABSTRACT Aim Liver cirrhosis is a severe condition that often
Oki Taniyama, Kotaro Kumagai, Shuji Kanmura, Yuko Nakamura, Hiromi Eguchi, Miho Uehara, Kyoko Meguro, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Seiichi Mawatari, Keisuke Yano, Satoshi Ieiri, Akio Ido   +15 more
wiley   +1 more source

Effectiveness of Bimekizumab in Psoriatic Arthritis: A Multicenter Real‐Life Study With Clinical and Ultrasound Evaluation in the Lazio Region, Italy

International Journal of Dermatology, EarlyView.
ABSTRACT Background Bimekizumab, a monoclonal antibody targeting interleukin (IL)‐17A and IL‐17F, has shown efficacy in psoriatic arthritis (PsA) clinical trials, but real‐world data on its effectiveness are limited. This study aimed to evaluate its real‐world effectiveness in PsA patients treated in dermatologic settings.
Giacomo Caldarola, Annunziata Dattola, Nicoletta Bernardini, Veronica Blundo, Elena Campione, Eleonora De Luca, Domenico Giordano, Alessandro Giunta, Gaia Moretta, Diego Orsini, Gianluca Pagnanelli, Antonio Richetta, Andrea Picchianti Diamanti   +12 more
wiley   +1 more source

Classification of Japanese type 1 diabetes based on clinical phenotypes and its association with diabetic complications: Across‐sectional study

Journal of Diabetes Investigation, EarlyView.
Distribution of cases by subgroup. Dots indicate each case. Lines connect each case to the centroid of each subgroup. BMI, body mass index; HbA1c, glycated hemoglobin. ABSTRACT Introduction Despite the increasing number of studies using machine learning to develop individualized treatment strategies, only a few have been conducted in patients with type
Takafumi Masuda, Naoto Katakami, Naohiro Taya, Kazuyuki Miyashita, Mitsuyoshi Takahara, Ken Kato, Iichiro Shimomura   +6 more
wiley   +1 more source

Anatomical design and production of a novel three‐dimensional co‐culture system replicating the human flexor digitorum profundus enthesis

Journal of Anatomy, EarlyView.
Anatomical morphometrics have been used to design and manufacture models of the flexor digitorum profundus tendon to bone insertion in vitro. This innovative approach can be used to design models of other enthesis regions with anatomical and clinical applicability.
Jeremy W. Mortimer, Philippa A. Rust, Jennifer Z. Paxton   +2 more
wiley   +1 more source

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source

Open re-rupture of the Achilles tendon after surgical treatment

Clinics and Practice, 2011
The rate of re-rupture of Achilles tendon after surgical treatment were reported to 1.7-5.6% previously. Re-rupture of Achilles tendon generally occurs subcutaneously.
Mitsuru Hanada, Masaaki Takahashi, Yukihiro Matsuyama   +2 more
doaj   +1 more source

Intramuscular tendon length in agonist–antagonist myoneural interface components in transtibial amputation: An anatomic study

Journal of Anatomy, EarlyView.
Interestingly, this study shows that tendons spanned over 75% of the distal muscle belly in all muscles, crucial for the innovative tibiotalar agonist–antagonist myoneural interface (AMI) construction. AMI simulates natural muscle–tendon interaction in amputees, improving prosthetic control despite anatomical constraints.
Viktoria Witowski, Lisa Lorbeer, Laura Schmid, Benedict Wilhelmi, Victor A. Hoursch, Matthew J. Carty, Hugh M. Herr, Roland Blumer, Massimo Sartori, Utku Ş. Yavuz, Corey L. Sullivan, Stephan Sehmisch, Andreas Schmiedl, Jennifer Ernst   +13 more
wiley   +1 more source

Long harvest of the flexor hallucis longus tendon in reconstructive foot & ankle surgery: A technique guide

Foot & Ankle Surgery: Techniques, Reports & Cases, 2022
Reconstruction of the Achilles tendon for insertional disease, acute and chronic ruptures, severe mangling limb trauma, and tendon loss from necrotizing infections often results in a significant reconstructive challenge.
Christopher Bibbo, DO, DPM, FACS, FAAOS, FACFAS
doaj  

Resorbable Bio‐Inductive Collagen Implant for Rotator Cuff Repair: What We Know, What We Need to Know, and the Path Forward

Orthopaedic Surgery, EarlyView.
This study aims to evaluate the quality of evidence regarding the safety, efficacy, and impact factors of applying the resorbable bio‐inductive collagen implant clinically to repair rotator cuff injuries. ABSTRACT Objectives Rotator cuff injuries are a leading cause of shoulder dysfunction, where bio‐inductive collagen implants have demonstrated ...
Jiaxin Tian, Fengxing Ding, Zhe Wang, Niu Muting, Chen Liu, Zipeng Ye, Huiang Chen, Caizhi Wu, Shaowei Yi, Yubo Fan, Jinzhong Zhao, Shiyi Cao, Bin Ma   +12 more
wiley   +1 more source