Results 51 to 60 of about 9,107,387 (291)

ACID-BASE BALANCE

, 2008
É imprescindível o conhecimento do diagnóstico e do tratamento das alterações do equilíbrio ácido-base. Nessa apresentação são abordados a causa, os efeitos e o tratamento da alcalose e da acidose, respiratória e metabólica.A profound knowledge about ...
Garcia, Luis Vicente, Évora, Paulo Roberto Barbosa   +1 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Intestinal oxygen exchange at condition of anemia

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2020
Relevance. Although disorders of oxygen delivery is one of the main factors in the development of intestinal dysfunction and bacterial translocation, the critical level of anemia and possibilities of it lowering remain unclear. Aim.
Oleksandr Rotar, Ruslan Sydorchuk, Vasyl Rotar, Svitlana Railianu, Oleksandr Hrama   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Different sources of sulfur in diets of adult cats on the urinary parameters and acid-base balance

Ciência Rural, 2018
: Urolithiasis is a common disorder in the veterinary clinic and is considered as one of the most frequently cause of morbidity. This disorder is closely associated with urinary pH and nutrition plays a key role in the control of this disease, because ...
Dóris Pereira Halfen, Alexandre de Mello Kessler, Luciano Trevizan, Juliana Toloi Jeremias, Thiago Henrique Annibale Vendramini, João Paulo Fernandes Santos, Patricia Massae Oba, Fabio Alves Teixeira, Marcio Antonio Brunetto, Aulus Cavalieri Carciofi   +9 more
doaj   +1 more source

The effect of acetate Ringer’s solution versus lactate Ringer’s solution on acid base physiology in infants with biliary atresia

BMC Pediatrics, 2021
Background The choice of the perioperative crystalloid is a key component of the fluid management and must take into account the liver function and the appearing metabolic disorders to avoid increase the liver extra metabolism.
Xiang Liu, Hongyan Cao, Xiaona Tan, Jing Shi, Li Qiao, Qi Zhang, Lei Shi   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Acid-base balance in acute ethylene glycol poisoning in rats treated with fomepizole

Journal of Medical Science, 2014
Introduction. Ethylene glycol (EG) is relatively nontoxic but undergoes a multi-step oxidation to toxic metabolites, aldehydes and acids. The accumulation of organic acids, mainly glycolates, leads to the development of profound, life-threatening ...
Jędrzej Przystanowicz, Barbara Zielińska-Psuja, Joanna Kowalówka-Zawieja, Karina Sommerfeld   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source