Results 91 to 100 of about 391,178 (308)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

STUDY OF ELECTROCHEMICAL BEHAVIOR OF VI-B GROUP METAL OXIDES IN TUNGSTATE MELT

Studia Universitatis Babes-Bolyai Chemia
Thermodynamic assessment of the probability of interaction of metal oxides of group VI-B with tungstate melts, the results of the study of the acid-base properties of tungstate melt by potentiometric method.
Victor MALYSHEV, Angelina GAB, Ana-Maria POPESCU, Virgil CONSTANTIN   +3 more
doaj   +1 more source

Towards Understanding the Origin of Genetic Languages

, 2008
Molecular biology is a nanotechnology that works--it has worked for billions of years and in an amazing variety of circumstances. At its core is a system for acquiring, processing and communicating information that is universal, from viruses and bacteria
Patel, Apoorva D.
core   +1 more source

Co-populated Conformational Ensembles of β(2)-Microglobulin Uncovered Quantitatively by Electrospray Ionization Mass Spectrometry [PDF]

, 2004
Ordered assembly of monomeric human β(2)-microglobulin (β(2)m) into amyloid fibrils is associated with the disorder hemodialysis-related amyloidosis. Previously, we have shown that under acidic conditions (pH
Bjorkman, Cech, Chiti, Chiti, Chowdhury, Dobo, Dobson, Esposito, Felitsyn, Fenn, Fenn, Floege, Ganem, Gejyo, Gejyo, Gorevic, Goto, Grandori, Grandori, Hill, Hoshino, Jones, Kad, Kad, Kaltashov, Karlsson, Katou, Khan, Konermann, Konermann, Kraulis, Mayer, McParland, McParland, Mirza, Morgan, Ohashi, Pitkanen, Robinson, Samalikova, Samalikova, Saper, Selkoe, Siuzdak, Smith, Wanker, Yamaguchi   +46 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Base Excess and Beyond: Evolving Concepts in Acid-base Analysis

Turkish Journal of Anaesthesiology and Reanimation
Base excess (BE), a marker used to detect metabolic acid-base disturbances, is also known to predict mortality in critically ill patients; the traditional concept, originally based on the Henderson-Hasselbalch model, has been further refined through ...
Özge Köner, Tuğhan Utku, Kubilay Demirağ, Levent Döşemeci   +3 more
doaj   +1 more source

S, Zn, Cr, Cu and Fe changes during fluvial sediments oxidation [PDF]

Ciencia del Suelo, 2009
Acidification of dredged sediments which have been disposed on land is highly dependent on redox shifts. The aim of the present work was to assess changes in sulphur, metal speciation (Zn, Fe, Cr y Cu) and acidity caused by a polluted sediment oxidation ...
María Pía Di Nanno, Gustavo Curutchet, Silvia E Ratto   +2 more
doaj  

Enhanced oil recovery from high-viscosity oil deposits by acid systems based on surfactants, coordining solvents and complex compounds

Georesursy, 2019
Physicochemical aspects of enhanced oil recovery (EOR) from heavy high-viscosity deposits, developed in natural mode and combined with thermal methods, using systems based on surface-active substances (surfactants), coordinating solvents and complex ...
Lyubov K. Altunina, Vladimir A. Kuvshinov, Lyubov A. Stasyeva, Ivan V. Kuvshinov   +3 more
doaj   +1 more source

Polymer Dissolution Model: An Energy Adaptation Of The Critical Ionization Theory [PDF]

, 2009
The current scale of features size in the microelectronics industry has reached the point where molecular level interactions affect process fidelity and produce excursions from the continuum world like line edge roughness (LER).
Bonnecaze, R. T., Chauhan, S., Mack, C., Scheer, S., Somervell, M., Willson, C. G.   +5 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source