Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 [PDF]
Clinical and Experimental Emergency Medicine, 2018 Objective Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO ...
Hyukhoon Kim +5 more
doaj +1 more source
The study of phenylboronic acid optical properties towards creation of a glucose sensor [PDF]
, 2014 The article presents influence of pH and glucose concentration on phenylboronic acid (PBA) fluorescence studied by steady-state and time-resolved measurements. Fluorescence of PBA decreases with growing pH.
Kur-Kowalska, Katarzyna +2 more
core
Review of catalytic systems and thermodynamics for the Guerbet condensation reaction and challenges for biomass valorization [PDF]
, 2015 The Guerbet condensation reaction is an alcohol coupling reaction that has been known for more than a century. Because of the increasing availability of bio-based alcohol feedstock, this reaction is of growing importance and interest in terms of value ...
Gabriels, D +4 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Physics of base-pairing dynamics in DNA
, 2016 As a key molecule of Life, Deoxyribonucleic acid (DNA) is the focus of numbers of investigations with the help of biological, chemical and physical techniques.
Destainville, Nicolas, Manghi, Manoel
core +3 more sources
Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]
, 2003 Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Cooper, M.A. +5 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Участие на калций и магнезий в киселинно-алкалното равновесие в Канелени горски почви
Почвознание, агрохимия и екология, 2010 Soils of South Bulgaria (Luvisols and Planosols, WRBSR, 2006) are known as rather different regarding nature оr quantity of their clay minerals. In this article, аn attempt to find out а general equation for the dependence between pH of soil and the ...
МАРИЯ ТАНЕВА +2 more
doaj
Homogeneous CO Hydrogenation: Dihydrogen Activation Involves a Frustrated Lewis Pair Instead of a Platinum Complex [PDF]
, 2010 During a search for conditions appropriate for Pt-catalyzed CO reduction using dihydrogen directly, metal-free conditions were discovered instead.
Bercaw, John E. +2 more
core +1 more source