Results 71 to 80 of about 1,113,832 (265)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Siliao yanjiu, 2022 The study was to optimize the extraction process of chlorogenic acid from Peristrophe japonica by response surface methodology.The experiment used Peristrophe japonica as raw material, ethanol as solvent, and extraction rate of chlorogenic acid in ...
GAO Lin-xiao +3 more
doaj
Study on the influence factors for chlorogenic acid content in Shuanghuanglian oral liquid
Journal of Hebei University of Science and Technology, 2015 This paper aims to find the reason of the decrease of chlorogenic acid in Shuanghuanglian oral liquid, and to enhance the stability of chlorogenic acid by improving the preparation process.
Jianchen LI +4 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Anion-exchange extraction of mefenamic acid
Журнал Белорусского государственного университета: Химия, 2019 Anion-exchange extraction of mefenate anions with toluene solutions of trinonyloctadecylammonium picrate was studied. It has been established that the introduction of solvents with acid properties – chloroform and n-octylalcohol – into the organic phase ...
Alyaksandr L. Gulevich +3 more
doaj
The Extraction of Uric Acid in Acute Pneumonia [PDF]
The American Journal of the Medical Sciences, 1897 n ...
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source