Results 31 to 40 of about 591,302 (312)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Specified staged acid fracturing of horizontal well for strong-heterogeneity carbonate gas reservoirs: A case study on the gas reservoir of the fourth member of Upper Sinian Dengying Formation in Gaoshiti-Moxi area of the central Sichuan Basin

Natural Gas Industry B, 2021
The carbonate gas reservoir of the fourth Member of Upper Sinian Dengying Formation (hereinafter referred as “Deng 4 Member”) is characterized by deep burial, high temperature, low porosity, low permeability and strong heterogeneity in the Gaoshiti-Moxi ...
Hong Yue, Fei Liu, Huali Zhang, Changlin Zhou, Weihua Chen, Zhenhua Xiao   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Investigation of Gas-Sensing Property of Acid-Deposited Polyaniline Thin-Film Sensors for Detecting H2S and SO2

Sensors, 2016
Latent insulation defects introduced in manufacturing process of gas-insulated switchgears can lead to partial discharge during long-time operation, even to insulation fault if partial discharge develops further.
Xingchen Dong, Xiaoxing Zhang, Xiaoqing Wu, Hao Cui, Dachang Chen   +4 more
doaj   +1 more source

A characteristic analysis between acidolysis gas and absorbed gas and its application to gas source correlation in Mao 1 member, Fuling area, Sichuan Basin

Natural Gas Industry B, 2020
The acidolysis gas in source rocks is the desorbed hydrocarbon gas in non-connected pores and carbonate crystal lattice, while the absorbed gas lies in the connected pores and is absorbed by surface.
Wei Yao, Jin Xu, Wenqian Xia, Qiang Wang, Dan Rao, Qianglu Chen   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dual Porosity Simulation of Gravity Drainage Mechanism Induced by Geological Acid Gas Storage in Naturally Fractured Reservoirs

Energy Science & Engineering
Acid gases, containing CO2 and H2S, are by‐products of gas sweetening. Geological sequestration of these gases in naturally fractured reservoirs (NFRs) is a practical method to reduce greenhouse gas emission. An industrially accepted approach to simulate
Goran Shirzad, Mehdi Assareh
doaj   +1 more source

Effect of dietary formic acid on the in vitro ruminal fermentation parameters of barley-based concentrated mix feed of beef cattle

Journal of Applied Animal Research, 2018
This study aimed to determine the effect of 0 (FA0) and 1, 2, 4 or 8 mL/kg (FA1, FA2, FA4 and FA8) formic acid addition to barley-based concentrated mix feed on in vitro gas kinetics [gas production from quickly soluble fraction (agas), gas production ...
Kanber Kara, Serkan Özkaya, Sabri Erbaş, Erol Baytok   +3 more
doaj   +1 more source