Results 171 to 180 of about 3,140,410 (307)

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Real-time quantification of soluble tartrate-resistant acid phosphatase as a measure of osteoclastogenesis. [PDF]

Biotechniques
Roosma JA, Gafar H, Boruff MT, Quinn CR, Ashley JW.   +4 more
europepmc   +1 more source

Potential of root acid phosphatase activity to reduce phosphorus fertilization in maize cultivated in Brazil. [PDF]

PLoS One, 2023
Lopes E Silva L, Andrade JADC, Maltoni KL, Lannes LS.   +3 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Purification and Properties of an Acid Phosphatase of Micrococcus denitrificans Distinct from Thiamine Phosphate Phosphatase

, 1977
To determine whether the acid phosphatase in Micrococcus denitrificans participates in hydro-lysis of thiamine phosphate in the synthesis of thiamine pyrophosphate, acid phosphatase was purified 280-fold by conventional procedures, which removed thiamine
Takashi Kawasaki, Yoshiko Egi
core  

Modifying recombinant purple acid phosphatase using computational design. [PDF]

Eur Biophys J
Venkatramani A, Ali M, Predeina O, Molloy JC, Sormanni P, Hall EAH.   +5 more
europepmc   +1 more source

The acid phosphatases of rat liver [PDF]

Biochemical Journal, 1957
G A, GOODLAD, G T, MILLS
openaire   +2 more sources

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Alkaline phosphatase and acid phosphatase in health and disease - A systematic review. [PDF]

J Oral Maxillofac Pathol
Swetha S, Rao GN, Mahalakshmi V, Sathya R.   +3 more
europepmc   +1 more source

Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis. [PDF]

Commun Biol, 2023
Lu S, Andersen JF, Bosio CF, Hinnebusch BJ, Ribeiro JM.   +4 more
europepmc   +1 more source