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Nucleic Acid-Scavenging Hydrogels Accelerate Diabetic Wound Healing

Biomacromolecules, 2022
Chronic inflammation is a typical feature and a major impediment in refractory diabetic foot ulcer (DFU). High levels of extracellular cell-free nucleic acid (cfDNA) have recently been known to play a critical role in the cause of inflammation. Herein, we fabricated polyacrylamide-based cationic hydrogels and topically applied them to the ulcer of a ...
Hai Zhong   +6 more
openaire   +2 more sources

Cephalosporins are scavengers of hypochlorous acid

Biochemical Pharmacology, 1995
Potential scavenging properties of cephalosporins (i.e. cefamandole, cefotaxime and ceftriaxone) towards hypochlorous acid (HOCl) as well as the antibacterial activity of control and HOCl-reacted antibiotics were investigated. We found that these drugs, at therapeutically relevant concentrations, are indeed scavengers of HOCl, with ceftriaxone showing ...
LAPENNA, Domenico   +6 more
openaire   +3 more sources

Hypochlorous acid scavenging capacity of garlic

Phytotherapy Research, 2007
AbstractThe ability of the following aqueous garlic extracts to scavenge hypochlorous acid (HOCl) was studied: (a) unheated extract of raw garlic (RG), (b) heated extract of raw garlic (HRG), (c) extract of boiled garlic cloves (BG) and (d) extract of microwave‐treated garlic cloves (MG).
José, Pedraza-Chaverrí   +2 more
openaire   +2 more sources

Polycationic Nanofibers for Nucleic Acid Scavenging

Biomacromolecules, 2016
Dying cells release nucleic acids (NA) and NA-containing complexes that activate inflammatory pathways of immune cells. Sustained activation of these pathways contributes to chronic inflammation frequently encountered in autoimmune and inflammatory diseases.
Jennifer G, Jackman   +5 more
openaire   +2 more sources

Chlorogenic Acid as a Natural Scavenger for Hypochlorous Acid

Biochemical and Biophysical Research Communications, 1995
The effect of chlorogenic acid (CGA) on the killing of Escherichia coli by hypochlorous acid (HOCI) was examined. CGA prevented E. coli from bactericidal action of HOCI in a concentration-dependent manner. HOCI reacted rapidly with CGA. By comparison with the one- and two-electron oxidation products produced by peroxidase and phenolase reactions ...
Y, Kono   +4 more
openaire   +2 more sources

Rapid scavenging of peroxynitrous acid by monohydroascorbate

Free Radical Biology and Medicine, 2003
The reaction of peroxynitrous acid with monohydroascorbate, over the concentration range of 250 microM to 50 mM of monohydroascorbate at pH 5.8 and at 25 degrees C, was reinvestigated and the rate constant of the reaction found to be much higher than reported earlier (Bartlett, D.; Church, D. F.; Bounds, P. L.; Koppenol, W. H. The kinetics of oxidation
Christophe R, Kurz   +4 more
openaire   +2 more sources

Citric acid: A promising copper scavenger

Computational and Theoretical Chemistry, 2018
Abstract In this investigation, the capacity of citric acid as copper scavenger is analyzed. For the copper scavenger capacity, the formation of the chelate complexes is studied using the Gibbs free energies. The chelates may be formed since the formation reactions are all exergonic.
Ana Martínez   +2 more
openaire   +1 more source

Hydroxybenzoic acids and their derivatives as peroxynitrite scavengers

Free Radical Biology and Medicine, 2014
A social challenge of the 21(st) century is to reduce the incidence of chronic diseases. A balanced diet rich in polyphenols could contribute to reduce the risk and to the prevention of diabetes, coronary heart disease, cancer, Alzheimer's diseases and cataract(1).
Beáta, Hubková   +4 more
openaire   +2 more sources

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