Results 161 to 170 of about 1,733,689 (305)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Structural Evidence of Interanionic Hydrogen Bonding in Phosphoric Acid Solutions. [PDF]

J Am Chem Soc
Kim P, Kang R, Carter-Fenk K, Wilson KR, Head-Gordon M, Ahmed M.   +5 more
europepmc   +1 more source

Spectral signatures of excess-proton waiting and transfer-path dynamics in aqueous hydrochloric acid solutions. [PDF]

Nat Commun, 2022
Brünig FN, Rammler M, Adams EM, Havenith M, Netz RR.   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessing the hydrolysis of PDO threads combined with injectable hyaluronic acid solutions for facial rejuvenation. [PDF]

Braz Dent J
Delaroli FPB, Costa APC, Setti JBM, Freitas PM, Arana-Chavez VE, Lobo MM.   +5 more
europepmc   +1 more source

Chitin Cryogels Prepared by Regeneration from Phosphoric Acid Solutions. [PDF]

Materials (Basel), 2021
Tyshkunova IV, Chukhchin DG, Gofman IV, Pavlova EN, Ushakov VA, Vlasova EN, Poshina DN, Skorik YA.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Sodium Dodecylbenzene Sulfonate-Mediated Self-Assembly of Silk Particles from Formic Acid Solutions into Robust Films. [PDF]

Polymers (Basel)
Malaspina R, Alunni Cardinali M, Libera V, Comez L, Petrillo C, Paciaroni A, Sassi P, Valentini L.   +7 more
europepmc   +1 more source

Evaluation of Non-Cross Linked Xeno-Free Hyaluronic Acid Solutions as Visco Elastic Biomaterials.

J Pharm Bioallied Sci, 2023
Mohan SP, Palaniappan A.
europepmc   +1 more source

Corrosion Behavior of the AlCoCrFeNi_2.1 Eutectic High-Entropy Alloy in Chloride-Containing Sulfuric Acid Solutions at Different Temperatures. [PDF]

Materials (Basel), 2022
Song L, Hu W, Zhang X, Liao B, Wan S, Kang L, Guo X.   +6 more
europepmc   +1 more source