Results 121 to 130 of about 196,806 (297)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Electrochemical CO₂ reduction in acidic media: a perspective

The electrochemical CO2 reduction reaction (eCO2RR) is a promising approach for converting CO2 to useful chemicals and, hence, achieving carbon neutrality.
Peter, Sebastian C., Dutta, Nilutpal
core   +1 more source

The pH-Insensitive Antimicrobial and Antibiofilm Activities of the Frog Skin Derived Peptide Esc(1-21): Promising Features for Novel Anti-Infective Drugs

Antibiotics
The number of antibiotic-resistant microbial infections is dramatically increasing, while the discovery of new antibiotics is significantly declining. Furthermore, the activity of antibiotics is negatively influenced by the ability of bacteria to form ...
Maria Rosa Loffredo, Floriana Cappiello, Giacomo Cappella, Elisabetta Capuozzo, Luisa Torrini, Fabiana Diaco, Yuanpu Peter Di, Maria Luisa Mangoni, Bruno Casciaro   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

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مجلة علوم ذي قار, 2019
In this research it has been determined the optimum conditions for extraction of benzoate (sodium benzoate) that used as food additives and beverages.In extraction process two organic solvents used (hexane and ether) and used (HCl, HNO ) as acidic ...
بسام فرعون
doaj  

Influence of molar ratio and pH on physicochemical characteristics of genipin-derived pigments formed at cold and mild temperatures

Food Chemistry Advances
The reaction genipin-amino acids at acidic-alkaline conditions at 7; 37 °C was assessed and products were analyzed at the nanoscale (hydrodynamic size, concentration, and size distribution) for the first time, including FTIR analysis.
Ana Mayela Ramos-de-la-Peña, Alfredo Santana-Reynoso, José González-Valdez, Oscar Aguilar, Catherine M.G.C. Renard, Cuauhtémoc Licona-Cassani   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Securing interfacial cationic copper for acidic CO2 reduction to ethylene

Nature Communications
Electrocatalytic reduction of CO2 to ethylene utilizing Cu-based catalysts in acidic media demonstrates considerable potential for addressing energy and environmental challenges.
Sifan Wang, Zhecheng Fang, Can Yu, Bolong Li, Jianghao Wang, Jiaji Zhang, Zihao Zhang, Wenhua Zhou, Siyu Yao, Weiyu Song, Zhao-Qing Liu, Dangguo Cheng, Jie Fu   +12 more
doaj   +1 more source