Results 121 to 130 of about 17,547,833 (304)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mediatization: theorizing the interplay between media, culture and society

, 2015
In response to Deacon and Stanyer’s article ‘Mediatization: Key Concept or Conceptual Bandwagon?’ we argue that they build their criticism on a simplified methodology.
Lundby, Knut, Hepp, Andreas, Hjarvard, Stig   +2 more
core   +1 more source

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مجلة علوم ذي قار, 2019
In this research it has been determined the optimum conditions for extraction of benzoate (sodium benzoate) that used as food additives and beverages.In extraction process two organic solvents used (hexane and ether) and used (HCl, HNO ) as acidic ...
بسام فرعون
doaj  

The pH-Insensitive Antimicrobial and Antibiofilm Activities of the Frog Skin Derived Peptide Esc(1-21): Promising Features for Novel Anti-Infective Drugs

Antibiotics
The number of antibiotic-resistant microbial infections is dramatically increasing, while the discovery of new antibiotics is significantly declining. Furthermore, the activity of antibiotics is negatively influenced by the ability of bacteria to form ...
Maria Rosa Loffredo, Floriana Cappiello, Giacomo Cappella, Elisabetta Capuozzo, Luisa Torrini, Fabiana Diaco, Yuanpu Peter Di, Maria Luisa Mangoni, Bruno Casciaro   +8 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The Study of Media Audiences

, 2012
The aim of this one semester course is to provide an introductory guide to important theoretical and methodological concerns that have influenced audience studies alongside some of the seminal work on the persuasive power of ...
Media and Communications
core  

Influence of molar ratio and pH on physicochemical characteristics of genipin-derived pigments formed at cold and mild temperatures

Food Chemistry Advances
The reaction genipin-amino acids at acidic-alkaline conditions at 7; 37 °C was assessed and products were analyzed at the nanoscale (hydrodynamic size, concentration, and size distribution) for the first time, including FTIR analysis.
Ana Mayela Ramos-de-la-Peña, Alfredo Santana-Reynoso, José González-Valdez, Oscar Aguilar, Catherine M.G.C. Renard, Cuauhtémoc Licona-Cassani   +5 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Production of acidic xylo-oligosaccharides by a family 10 endoxylanase from Thermoascus aurantiacus and use as plant growth regulators

, 2002
Neutral and acidic oligosaccharides were obtained from birchwood xylan by treatment with an endoxylanase, family 10 class, from Thermoascus aurantiacus.
Pistola, E, Katapodis, P,, Pistola, E ,, Kekos, D ,, Kintzios, S, Kekos, D, Katapodis, P, Christakopoulos, P, Kavarnou, A, Christakopoulos, Paul, Kavarnou, A ,, Macris, B.J,, Macris, BJ, Kintzios, S,   +13 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source