Results 101 to 110 of about 17,547,833 (304)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Key Issues and Approaches to Media Studies Mod 1 Unit 6

, 2010
This module introduces a variety of influential, competing ways of thinking about the media within the broad area of social science research, but drawing also on other disciplines.
Department of Media and Communications
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Imagining the Global: Transnational Media and Popular Culture Beyond East and West [PDF]

, 2014
Based on a series of case studies of globally distributed media and their reception in different parts of the world, Imagining the Global reflects on what contemporary global culture can teach us about transnational cultural dynamics in the 21st century.
Darling-Wolf, Fabienne
core   +1 more source

Influence of varying oral pH conditions on the material stability of thermoplastic orthodontic aligners: an in vitro study

BMC Oral Health
Background Clear thermoplastic orthodontic aligners are widely used due to their aesthetic appeal and patient comfort; however, exposure to chemically diverse intraoral environments may compromise their physical, aesthetic, and chemical stability.
Dhruv Ahuja, Bhawna Negi, Anjana Goyal, Puneet Batra, Ashith MV, Kumar Rakshak Anand, Khushi Gupta, Bhoomi Pitanjali Singh, Areeba Parvez   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

EFFECT OF CHEMICAL TREATMENT ON RICE HUSK (RH) REINFORCED POLYETHYLENE (PE) COMPOSITES

BioResources, 2010
In this study rice husk reinforced polyethylene composites and their test specimens were manufactured using a single screw extruder and an injection molding machine, respectively. Raw rice husk was chemically treated with benzene diazonium salt in alkali,
Md. Rezaur Rahman, Md. Nazrul Islam, Md. Monimul Huque, Sinin Hamdan   +3 more
doaj  

Dissolution kinetics of coal and limestone samples from Kogi state, Nigeria

African Scientific Reports
This work is concerned with the dissolution behaviour and kinetics of Okobo coal and Obajana limestone from Kogi State, Nigeria, within acidic, basic, and neutral media. This was achieved using hydrochloric acid and sodium hydroxide with distilled water,
Anthony Ugbedeojo Atumeyi, Adams Udoji Itodo, Rufus Sha'Ato, Raymond Ahulle Wuana   +3 more
doaj   +1 more source