Characterization of the life-cycle stages of the coccolithophore Emiliania huxleyi and their responses to Ocean Acidification [PDF]
Sebastian Rokitta
openalex
Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge +14 more
wiley +1 more source
Genotype and symbiont composition rather than environment influence susceptibility to stony coral tissue loss disease in coral restoration broodstock. [PDF]
Eaton KR +4 more
europepmc +1 more source
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan +20 more
wiley +1 more source
Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies. [PDF]
Hu Y, Yang Z, Wang X, Li X, Wei M.
europepmc +1 more source
Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification [PDF]
Delputte, Peter +3 more
core
F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source
Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism. [PDF]
Goering ER +4 more
europepmc +1 more source

