Results 201 to 210 of about 428,013 (350)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Quality Evaluation of Packaged Pimento-Paste Stuffed Green Manzanilla Olives in KCl, CaCl₂, and MgCl₂ Brines. [PDF]

Foods
López-López A, Moreno-Baquero JM, Garrido-Fernández A.   +2 more
europepmc   +1 more source

Substituent and solvent effects on Lewis acidity of p-substituted anilines: symmetry of interactions [PDF]

, 1979
Guillaume G. Launay, Bruno Wojtkowiak, Tadeusz M. Krygowski   +2 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Applying Factorial Modeling to the Optimization of Textural Descriptors and Sensations Relative to Obtaining the Experimental Prototype of Chickpea Puree with Avocado. [PDF]

Foods
Iancu ML, Mironescu ID.
europepmc   +1 more source

Study of Reduction the Acidity from Residual Oil for Biodiesel Production Using Fractional Factorial Design

, 2013
T. A. R. da Silva, Waldomiro Borges Neto
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

About a Trillion Times More Acidic than Expected? On the Difference Between the Hammett H₀ and the Unified pH Acidity of Sulfuric Acid. [PDF]

Angew Chem Int Ed Engl
Radtke V, Bäuerle M, Stroh R, Kienzle T, Himmel D, Heering A, Nerut J, Lust E, Leito I, Krossing I.   +9 more
europepmc   +1 more source

Assessment of hydroxymethylfurfural and total acidity of bee (Apis mellifera L.) honey stored for 12 months.

, 2010
Karoline Mikaelle de Paiva Soares, Edna María Mendes Aroucha, C. R. Lucas   +2 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source