Results 151 to 160 of about 1,246,813 (303)

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Synergistic roles of aquaporin 5 and intra‐ and extracellular carbonic anhydrases in promoting CO2 diffusion across the Xenopus oocyte plasma membrane

The Journal of Physiology, EarlyView.
Abstract figure legend Fick's law: JCO2=PM*,CO2±hAQP5·([CO2]os±bCA−[CO2]is±hCAII)TransmembraneCO2gradient${J}_{{\mathrm{CO}}_{2}}=\underset{\pm \mathrm{hAQP}5}{\underset{}{{P}_{\mathrm{M}^\ast ,{\mathrm{CO}}_{2}}}}\, \cdot \underset{\mathrm{Transmembrane}\ {\mathrm{CO}}_{2}\ \mathrm{gradient}}{\underset{}{(\underset{\pm \mathrm{bCA}}{\underset ...
Deng‐Ke Wang, Fraser J. Moss, Walter F. Boron   +2 more
wiley   +1 more source

Inhaled β-agonist therapy and respiratory muscle fatigue as under-recognised causes of lactic acidosis

BMJ Case Reports, 2013
Emily S. Lau, Jeffrey Mazer, G. Carino
semanticscholar   +1 more source

Elevated carotid body tonic activity contributes to ventilatory acclimatization and de‐acclimatization to high altitude at rest and during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend Participants spent 13 days at high altitude (3800 m), where the reduced inspired oxygen pressure (↓PiO2$ \downarrow {P_{{\mathrm{i}}{{\mathrm{O}}_2}}}$) which elicited ventilatory acclimatization and increased inhibition of ventilation by transient hyperoxia (ΔV̇E$\Delta {\dot V_{\mathrm{E}}}$).
Ayechew A. Getu, L. Madden Brewster, Travis D. Gibbons, James D. Anholm, Michael Stembridge, Philip N. Ainslie, Jay M. J. R. Carr   +6 more
wiley   +1 more source

Association between acute respiratory acidosis and hyperkalemia during esophageal cancer surgery in the prone position: A multicenter retrospective observational study protocol. [PDF]

PLoS One
Okamoto S, Tochii T, Nakada J, Note H.
europepmc   +1 more source

Interaction of Metabolic and Respiratory Acidosis with &agr; and &bgr;-adrenoceptor Stimulation in Rat Myocardium

Anesthesiology, 2012
M. Biais, R. Jouffroy, A. Carillion, S. Feldman, Aude Jobart-Malfait, B. Riou, J. Amour   +6 more
semanticscholar   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Kidney disease impairs tendon function in rats

The Journal of Physiology, EarlyView.
Abstract figure legend This study demonstrates for the first time that tendon strength is reduced in a rodent model of chronic kidney disease (8 weeks of 0.25% adenine feeding) and confirms concurrent dysfunction in muscle and bone. These findings provide novel characterization of multiple tissues, paving the way for future investigations into the ...
Christopher M. T. Hayden, Natalie K. Gilmore, Benjamin Osipov, Sarah E. Brashear, Marc Gorge, Juang‐Yu Jen, Lucas R. Smith, Blaine A. Christiansen, Baback Roshanravan, Keith Baar   +9 more
wiley   +1 more source