Results 161 to 170 of about 159,303 (377)

Artificial Intelligence Revolutionizes Anti‐Infective Drug Discovery: From Target Identification to Lead Optimization

iMetaMed, EarlyView.
Artificial intelligence (AI) technology is revolutionizing antimicrobial drug development. In response to increasingly severe antimicrobial resistance challenges, AI can efficiently predict pathogen evolutionary trends, identify potential drug targets, and accelerate compound design and optimization, thereby significantly shortening the development ...
Kexin Li, Quan Yuan, Chang Qi, Ying Shi, Hong Yang, Anqi Lin, Shuofeng Yuan   +6 more
wiley   +1 more source

Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review [PDF]

, 2018
Background Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance ...
B Cohen, B Nolan, B Rosen, BM Isaac, BO Nomamiukor, C Costelloe, C Curtis, C García-Rey, C Kristiansson, D Moher, DM Young, DO Duerink, E Brunner, E Castro-Sánchez, E Castro-Sánchez, E Gebeyehu, E Mangrio, ES Lestari, F Barah, FM Chen, G Alvarez-Uria, HK Parsons, IN Okeke, J O'Neill, JC Seidman, JC Semenza, JLF Antunes, JP Bagger, JR Covvey, KM McMullen, L Boyanova, M Karanikolos, M Kempf, M Marmot, MA Trecker, MB Planta, MG Baker, O Henig, P Chatterjee, P Nilsson, PJ Hotez, R Kumar, R Mehdinapah, S Bratu, S Jourdain, S Willems, SJ Eells, SS Huang, TB Souza, TP Van Boeckel, United Nations Development Programme (UNDP)   +50 more
core   +2 more sources

The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma

iMeta, EarlyView.
This study integrated metagenomic and proteomic profiling of 185 colorectal tissue samples—spanning adenoma (A), tumor (T), and para‐tumor (P)—to characterize multi‐kingdom microbiome and host protein dynamics in colorectal cancer (CRC). In total, 4057 bacterial, 61 fungal, 108 archaeal, and 374 viral species were identified, revealing CRC‐specific ...
Di Wu, An‐Jun Wang, De‐Chao Bu, Yan‐Yan Sun, Chen‐Hao Li, Yue‐Mei Hong, Shan Zhang, Shi‐Yang Chen, Jin‐An Zhou, Tian‐Yi Zhang, Min‐Hao Yu, Yong‐Jing Ma, Xiu‐Li Wang, Jia Xu, Wei He, Christopher Heeschen, Jian‐Feng Chen, Wen‐Jun Mao, Hui Ding, Wen‐Juan Wu, Yi Zhao, Hui Wang, Ning‐Ning Liu   +22 more
wiley   +1 more source

Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains

BMC Microbiology
Resistance mechanisms are a shelter for Acinetobacter baumannii to adapt to our environment which causes difficulty for the infections to be treated and WHO declares this organism on the top of pathogens priority for new drug development. The most common
Neveen M. Saleh, Hadeer Ezzat, Gharieb S. El-Sayyad, Hamdallah Zedan   +3 more
doaj   +1 more source

The clinical characteristics of Acinetobacter bacteremia differ among genomospecies: A hospital-based retrospective comparative analysis of genotypically identified strains

Journal of Microbiology, Immunology and Infection, 2019
Background/purpose: Acinetobacter is an aerobic, gram-negative coccobacillus, which causes nosocomial infections including bacteremia. Recent development of molecular techniques has made classification of the Acinetobacter genomospecies possible, but ...
Yusuke Koizumi, Daisuke Sakanashi, Tomoko Ohno, Atsuko Yamada, Arufumi Shiota, Hideo Kato, Mao Hagihara, Hiroki Watanabe, Nobuhiro Asai, Masaya Watarai, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu, Hiroshige Mikamo   +13 more
doaj   +1 more source

Bacterial Biofilm and its Clinical Implications [PDF]

, 2018
Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable ...
Shakibaie, Prof
core  

OXA β-lactamases [PDF]

, 2014
The OXA β-lactamases were among the earliest β-lactamases detected; however, these molecular class D β-lactamases were originally relatively rare and always plasmid mediated.
Brink AJ, Espinal P, Goncalves D, Lyon JA, Potron A, Summers DK   +5 more
core   +2 more sources

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies [PDF]

, 2019
Jhih‐Hang Jiang, Karl A. Hassan, Stephanie L. Neville, Thusitha Rupasinghe, Varsha Naidu, Victoria G. Pederick, Marjan Khorvash, Jonathan J. Whittall, James C. Paton, Ian T. Paulsen, Christopher A. McDevitt, Anton Y. Peleg, Bart A. Eijkelkamp   +12 more
openalex   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

A Tractable Drosophila Cell System Enables Rapid Identification of Acinetobacter baumannii Host Factors [PDF]

, 2020
Qing‐Ming Qin, Jianwu Pei, Gabriel Gomez, Allison C. Rice‐Ficht, Thomas A. Ficht, Paul de Figueiredo   +5 more
openalex   +1 more source