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Acitretin is converted to etretinate only during concomitant alcohol intake
British Journal of Dermatology, 2000Per B Brockhoff
exaly
Annales de dermatologie et de venereologie, 2001
Acitretin (Soriatane(R)) is an aromatic retinoïd (carboxylic acid metabolite of etretinate). Acitretin has a terminal elimination half-life of about 55 to 60 hours. However, concomitant intake of alcohol induces transformation to etretinate (lipophilic ester) which has a longer terminal elimination half life (84 to 168 days).
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Acitretin (Soriatane(R)) is an aromatic retinoïd (carboxylic acid metabolite of etretinate). Acitretin has a terminal elimination half-life of about 55 to 60 hours. However, concomitant intake of alcohol induces transformation to etretinate (lipophilic ester) which has a longer terminal elimination half life (84 to 168 days).
openaire +1 more source
Concurrent use of methotrexate and acitretin revisited
Journal of Dermatological Treatment, 2008Nico Shary
exaly
An updated review of acitretin – a systemic retinoid for the treatment of psoriasis
Expert Opinion on Drug Metabolism and Toxicology, 2008Jenny Murase
exaly