Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties [PDF]
Frontiers in Molecular Biosciences, 2022 ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini +16 more
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Selective expression and significance of ACKR2 in lung aerocytes [PDF]
Journal for ImmunoTherapy of CancerBackground ACKR2 is an atypical chemokine receptor that plays a significant role in regulating inflammation by binding to inflammatory CC chemokines and facilitating their degradation.
Alberto Mantovani +17 more
doaj +4 more sources
The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? [PDF]
Frontiers in Immunology, 2022 Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry out various ...
Arezoo Gowhari Shabgah +8 more
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Targeting the atypical chemokine receptor 2 (Ackr2) improves the benefit of anti-PD-1 immunotherapy in melanoma mouse model [PDF]
OncoImmunologyImmune checkpoint blockade (ICB) therapies, such as anti-PD-1, have transformed cancer treatment, but many patients do not respond due to a non-inflammatory tumor microenvironment (TME).
Muhammad Zaeem Noman +9 more
doaj +4 more sources
Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism. [PDF]
PLoS Biology, 2019 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee +7 more
doaj +4 more sources
Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways [PDF]
Arthritis Research & Therapy, 2023 Objectives Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA).
Hanna Johnsson +4 more
doaj +2 more sources
The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis [PDF]
Frontiers in Immunology, 2022 Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Tian Yu +9 more
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New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance [PDF]
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
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The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice [PDF]
Frontiers in ImmunologyIntroductionThe atypical chemokine receptor 2 (ACKR2) is a chemokine scavenger receptor, which limits inflammation and organ damage in several experimental disease models including kidney diseases.
Wenkai Xia +3 more
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Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets [PDF]
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
doaj +2 more sources