Results 31 to 40 of about 65 (61)

Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia

Scientific Reports
Lack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltrate the tumor microenvironment.
Alice Benoit, Audrey Lequeux, Phillip Harter, Guy Berchem, Bassam Janji   +4 more
doaj   +1 more source

Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion

Journal of Comparative Neurology, Volume 533, Issue 3, March 2025.
Schematic summary of the presence and characteristics of putative telocytes in human dorsal root ganglia (DRG). In‐depth in silico analysis of sequencing data suggests the presence of nine distinct telocyte subtypes in human DRG and defined more than 3000 predicted receptor–ligand interactions between neurons and telocytes.
Rainer V. Haberberger, Dusan Matusica, Stephanie Shiers, Ishwarya Sankaranarayanan, Theodore J. Price   +4 more
wiley   +1 more source

Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer‐Associated Fibroblasts

European Journal of Immunology, Volume 55, Issue 2, February 2025.
Cancer‐associated fibroblasts (CAFs) secrete chemokines that attract T cells. Here we show that the overexpression of atypical chemokine receptor 2 (ACKR2) by bystander cells scavenges key chemokines secreted by CAFs, including previously unreported ligands CXCL12 and CXCL1, and thereby protects T cells from chemoattraction by CAFs.
Richard Tang, Szun S. Tay, George Sharbeen, David Herrmann, Janet Youkhana, Paul Timpson, Phoebe A. Phillips, Maté Biro   +7 more
wiley   +1 more source

Multi‐omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

Cancer Communications, Volume 45, Issue 12, Page 1760-1766, December 2025.
Carine Ngo, Léo Colmet‐Daage, Julien Vibert, Clémence Hénon, Daniel Pissaloux, Alexander Valent, Jia Xiang Jin, Riwan Brillet, Julien Masliah‐Planchon, Gaëlle Pierron, Ludovic Lacroix, Etienne Rouleau, Cyril Roussel‐Simonin, Lilian Lecorgne, Clémence Astier, Marlène Garrido, Rastislav Bahleda, Benjamin Verret, Axel Le Cesne, Charles Honore, Matthieu Faron, Wolf Herman Fridman, Catherine Sautès‐Fridman, Jean‐Michel Coindre, Jean‐Yves Scoazec, Joshua J Waterfall, Franck Bourdeaut, Thomas G. P. Grünewald, Jean‐Yves Blay, Franck Tirode, Sophie Postel‐Vinay   +30 more
wiley   +1 more source

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science, Volume 12, Issue 1, January 9, 2025.
TLS is involved in the immune responses to cancer and other chronic inflammatory conditions, often associated with favorable clinical outcomes. In this context, dental pulp serves as an ideal model for chronic infection, and is used here to elucidate the specific contributions of TLS to the immune response and to identify the drivers of its formation ...
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
wiley   +1 more source

Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms

Cancer Communications, Volume 45, Issue 1, Page 15-42, January 2025.
Abstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe ...
Jiali Yao, Linlin Ji, Guang Wang, Jin Ding   +3 more
wiley   +1 more source

SARS‐CoV‐2 Activated Peripheral Blood Mononuclear Cells (PBMCs) Do Not Provoke Adverse Effects in Trophoblast Spheroids

American Journal of Reproductive Immunology, Volume 93, Issue 1, January 2025.
ABSTRACT Problem Although it is still uncertain whether Severe Acute Respiratory Coronavirus (SARS‐CoV‐2) placental infection and vertical transmission occur, inflammation during early pregnancy can have devastating consequences for gestation itself and the growing fetus.
Humblenoble Stembridge Ayuk, Susanne Arnold, Arkadiusz Pierzchalski, Mario Bauer, Violeta Stojanovska, Ana Claudia Zenclussen   +5 more
wiley   +1 more source

Orosomucoid 2 upregulation mediates liver injury‐induced colorectal cancer liver metastasis by promoting EMT and cell migration

Cancer Science, Volume 116, Issue 1, Page 44-55, January 2025.
We found that DILI promotes liver metastasis of colorectal cancer in a classic DILI mouse model. Further analysis using high‐throughput transcriptome sequencing and proteomics identified ORM2 as a key gene that promotes liver metastasis. ORM2 upregulation enhances tumor cell migration by promoting EMT of tumor cells and increasing the expression of ...
Xundong Wei, Lei Wang, Bing Yang, Yuanyuan Ma, Wei Yuan, Jie Ma   +5 more
wiley   +1 more source

CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice

Journal of Cellular and Molecular Medicine, Volume 28, Issue 24, December 2024.
ABSTRACT Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage‐associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell ...
Rahasudha Kannan, Amy J. Koh, Robert N. Kent III, Kaira Bhutada, Fatima Wasi, Leon Wagner, Kenneth Kozloff, Brendon M. Baker, Hernan Roca, Laurie K. McCauley   +9 more
wiley   +1 more source

Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia

Reproductive Biology and Endocrinology
Background Preeclampsia (PE) is a multifaceted pregnancy syndrome marked by multiple system involvement and a significant contributor to maternal mortality.
Jie Li, Meng-Meng Chen, Bingqiang Zhang, Yi Zhao   +3 more
doaj   +1 more source