Results 21 to 30 of about 71,028 (246)

Clinical Impact of Multiparametric Contrast‐Enhanced Dual‐Energy Computed Tomography in Arthritis Imaging: A Prospective Single‐Center Study

Arthritis &Rheumatology, EarlyView.
Objective We aimed to evaluate the influence of contrast‐enhanced dual‐energy computed tomography (CE‐DECT) in detecting and differentiating rheumatic joint diseases of the hand. Methods In this prospective study, patients with suspected arthritis of the hand were investigated consecutively alongside the standard clinical procedure.
Sevtap Tugce Ulas, Jürgen Mews, Sarah Ohrndorf, Robert Biesen, Katharina Ziegeler, Edgar Wiebe, Fabian Proft, Udo Schneider, Denis Poddubnyy, Torsten Diekhoff   +9 more
wiley   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

Logging In and Staying On: Exploring Immersive Virtual Influencers and How They Drive Consumers' Immersive Time

Journal of Consumer Behaviour, EarlyView.
ABSTRACT This study explores the role of virtual influencers (VIs) as critical touchpoints for enhancing consumers' “Immersive Time (ImT)”—the time spent on virtual reality‐empowered immersive platforms. By blurring the lines between virtual and physical‐world experiences, immersive platforms transform VIs into “Immersive Virtual Influencers (IVIs ...
Henrietta Batinovic, Fabian Tingelhoff, Maik Hammerschmidt, Sofia Schöbel   +3 more
wiley   +1 more source

Impact of Species, Growth Conditions, and Plant Processing on the Phytochemistry and Antimicrobial Activity of Agrimonia Extracts

Chemistry &Biodiversity, EarlyView.
Agrimony is a medicinal herb known for its content of polyphenols and beneficial bioactivity, both of which can be strongly influenced by cultivation and processing. This study reveals that agrimony plant structures, species, and postharvest processing are the main drivers of observed variability in both phytochemical composition and antimicrobial ...
Anna Loučková, Jarmila Neugebauerová, Bára Křížkovská, Marie Zlechovcová, Kateřina Šebelová, Jan Lipov, Jitka Viktorová, Jana Hajšlová   +7 more
wiley   +1 more source

Antiaging, Wound‐Healing Properties and Chemical Characterization of Crude Hydroalcoholic Extract and Fractions of Myrcia neoobscura

Chemistry &Biodiversity, EarlyView.
ABSTRACT The aim of this study was to characterize the phytochemical profile and potential antiaging and wound‐healing activities of 70% hydroalcoholic crude extract (CHE) from Myrcia neoobscura leaves and its fractions—insoluble (IF), ethyl acetate (EAF), and aqueous (AF)—for use in phytocosmetics for skin application.
Larissa Mascarenhas Krepsky, Ana Helena Loos Moritz, Mayra Alice Corrêa Pitz, Letícia Bachmann, Diogo Alexandre Siebert, Paula Flegar, Stjepan Lešnjak, Ana Tirić, Amanda Tavares Germano, Mayara da Silva, Carlos Rafael Vaz, Larissa Benvenutti, André Luís de Gasper, José Roberto Santin, Isabel Daufenback Machado, Luciano Vitali, Marijana Zovko Končić, Michele Debiasi Alberton   +17 more
wiley   +1 more source

B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

ChemistryEurope, EarlyView.
Replacement of cobalt in the organometallic B12‐cofactor methylcobalamin (MeCbl) by rhodium furnishes a structural mimic with a significantly stronger metal–carbon bond. This synthetically challenging formal metal‐mutation converts the naturally optimized biological methyl‐transfer catalyst MeCbl into a designed antivitamin B12, an inactivated B12 ...
Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler   +8 more
wiley   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Acne fulminans [PDF]

Anais Brasileiros de Dermatologia, 2017
Acne fulminans is a rare and severe variant of acne. In Brazilian medical journals, cases are infrequently reported, confirming its rarity. We followed five young male patients with this severe variant of cutaneous lesions, accompanied by also severe systemic symptoms: fever, anorexia, weight loss, and arthralgia.
openaire   +5 more sources

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source