Results 121 to 130 of about 2,497 (169)

Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine

Journal of Ethnopharmacology, 2012
To investigate the influence of paeoniflorin (major bioactive component of Paeonia lactiflora Pall.) on the pharmacokinetic behavior of aconitine (major toxic and bioactive component of Aconitum carmichaeli Debx.) and potential detoxifying effect of paeoniflorin on the acute toxicity of aconitine, which may provide in depth understanding to the ...
Ying Xie, Yuen Fan Wong, Zhong Qiu Liu
exaly   +3 more sources

A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM

Forensic Science International, 1996
Described here is a fatal case of accidental aconitine poisoning following the ingestion of aconite, Torikabuto, mistaken for an edible grass, Momijigasa. A 61-year-old man developed symptoms of nausea, diarrhea, and discomfort of the body about 2 h after the ingestion and was taken to an emergency room.
Kunio Gonmori, Yoshimi Saito, Michinao Mizugaki   +2 more
exaly   +3 more sources

Quantitative analysis of aconitine in body fluids in a case of aconitine poisoning

Forensic Science, Medicine, and Pathology, 2019
Aconitine belongs to the Aconitum alkaloids and is a natural toxic substance. Aconitine has been used as a traditional medicine in East Asian culture. Today, aconitine is still in use with or without a prescription, in the Republic of Korea. Here we present a case report of accidental death due to acute aconitine poisoning.
Yong Soo Cho, Byeong Jo Chun, Jeong Mi Moon   +2 more
exaly   +3 more sources

Reflections on the aconitine poisoning

Journal of Forensic Sciences, 2021
AbstractAconitine is a natural toxic substance belonging to the family of aconitum alkaloids, which is used in small doses by Traditional Chinese practitioners. We present a case of accidental death due to acute aconitine poisoning. A 65‐year‐old Chinese man presented to a medical clinic with fever and shoulder pain.
Yang, Ya, Zhang, Zhixiang, Liu, Chao, Zhao, Wei, Wang, Zhiyong, Cheng, Huafeng, Zhu, Shaohua, Xu, Hongfei   +7 more
openaire   +2 more sources

Advances on pharmacology and toxicology of aconitine

Fundamental & Clinical Pharmacology, 2022
AbstractAconitum alkaloids are considered to be the characteristic bioactive ingredients of Aconitum species, which are widely applied to the treatment of diverse diseases, and aconitine (AC) is found in most Aconitum plants. Research evidence shows that low‐dose AC has a good therapeutic potential in heart failure, myocardial infarction ...
Liuying Li, Limin Zhang, Tingting Liao, Chuantao Zhang, Keling Chen, Qun Huang   +5 more
openaire   +2 more sources

The positive inotropic effect of aconitine

Naunyn-Schmiedeberg's Archives of Pharmacology, 1983
1. The inotropic and electrophysiological effects of aconitine were measured in the isolated, isometrically contracting guinea-pig papillary muscle during the prearrhythmic phase of alkaloid action. 2. In muscles stimulated continually at 1 Hz, 1 mumol/l aconitine produced a positive inotropic effect that reached 38 +/- (SEM) 9% immediately before the ...
P, Honerjäger, A, Meissner
openaire   +2 more sources

Peculiarities of cardiotropic effect of aconitine

Bulletin of Experimental Biology and Medicine, 2000
In experiments on anesthetized cats, aconitine produced direct arrhythmogenic and cardiotoxic effects on the myocardium combined with indirect cardiotropic effects mediated via activation of extracardial nerves. Aconitine demonstrated pronounced cholinolytic properties and blocked vagal arrhythmogenic effect.
Y R, Sheikh-Zade, I L, Cherednik, P A, Galenko-Yaroshevskii   +2 more
openaire   +2 more sources

Regioselective demethylation of aconitine

Tetrahedron Letters, 1994
Abstract The regioselective demethylation of aconitine has been achieved with Lewis acids. Me 3 SiI afforded first 18- O -desmethyl- and then 16,18-di- O -desmethylaconitine, but AlCl 3 /NaI gave 16- O -desmethylaconitine first. The acetate and benzoate esters survived throughout these procedures. Aconitine decomposed on treatment with BBr 3 .
Ian S. Blagbrough, David J. Hardick, Susan Wonnacott, Barry V.L. Potter   +3 more
openaire   +1 more source

Aconitine

2000
Abstract Clinical A Ion channel syndrome (voltage-sensitive Na+ channels) B Acute encephalopathy (dystonia, confusion, death) The family Ranunculaceae contains a number of exception ally toxic herbaceous perennials, such as Aconitum napellus L. (monkshood), A. vulparia Reichb. ex Spreng (wolf’s bane)
openaire   +1 more source

THE BENZOYLOXY GROUP OF ACONITINE

Canadian Journal of Chemistry, 1963
not available
Y. Tsuda, Léo Marion
openaire   +1 more source