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Regioselective anthranoylation of demethylated aconitine: Novel analogues of aconitine inuline and methyllycaconitine

Tetrahedron Letters, 1994
Abstract The regioselective acylation of 18- O -desmethylaconitine has been achieved with isatoic anhydride to afford the corresponding anthranilate ester, an analogue of inuline. The aniline nitrogen was then incorporated into an S -methylsuccinimide moiety, to afford a novel methyllycaconitine/aconitine hybrid alkaloid.
David J. Hardick +3 more
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Aconitine and Wimbledon

2017
Aconitum napellus, monkswood, is the most poisonous of all plants – its roots especially so – because it produces the chemical aconitine. Aconitine is dangerous because it can be absorbed through the skin; just touching the leaves may lead to numbness in the fingers. There is no known antidote for aconitine.
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[Studies on hydrolysis of aconitine].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To find out hydrolysis regularity of aconitine.Aconitine was air-tighted and hydrolyzed in water for 8, 12, 16, 20, 24 h. The hydrolysis products were analyzed by HPLC-MS. A major hydrolysis product was isolated by alumina oxide column chromatography, and identified by 1H and 13C-NMR spectra.HPLC-MS analysis shows that the major hydrolysis products are
Qin-An, Huang +4 more
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Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Journal of Ethnopharmacology, 2022
Yabin Gao, Anzheng Nie
exaly

Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro

Journal of Ethnopharmacology, 2023
Wanyanhan Jiang, Fu Peng
exaly

Aconitine

2018
Rong Yan, Li Li, Guan-Hua Du
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The structure of aconitine