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A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM
Forensic Science International, 1996Described here is a fatal case of accidental aconitine poisoning following the ingestion of aconite, Torikabuto, mistaken for an edible grass, Momijigasa. A 61-year-old man developed symptoms of nausea, diarrhea, and discomfort of the body about 2 h after the ingestion and was taken to an emergency room.
N, Yoshioka +6 more
exaly +3 more sources
Reflections on the aconitine poisoning
Journal of Forensic Sciences, 2021AbstractAconitine is a natural toxic substance belonging to the family of aconitum alkaloids, which is used in small doses by Traditional Chinese practitioners. We present a case of accidental death due to acute aconitine poisoning. A 65‐year‐old Chinese man presented to a medical clinic with fever and shoulder pain.
Yang, Ya +7 more
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Advances on pharmacology and toxicology of aconitine
Fundamental & Clinical Pharmacology, 2022AbstractAconitum alkaloids are considered to be the characteristic bioactive ingredients of Aconitum species, which are widely applied to the treatment of diverse diseases, and aconitine (AC) is found in most Aconitum plants. Research evidence shows that low‐dose AC has a good therapeutic potential in heart failure, myocardial infarction ...
Liuying Li +5 more
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The positive inotropic effect of aconitine
Naunyn-Schmiedeberg's Archives of Pharmacology, 19831. The inotropic and electrophysiological effects of aconitine were measured in the isolated, isometrically contracting guinea-pig papillary muscle during the prearrhythmic phase of alkaloid action. 2. In muscles stimulated continually at 1 Hz, 1 mumol/l aconitine produced a positive inotropic effect that reached 38 +/- (SEM) 9% immediately before the ...
P, Honerjäger, A, Meissner
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Peculiarities of cardiotropic effect of aconitine
Bulletin of Experimental Biology and Medicine, 2000In experiments on anesthetized cats, aconitine produced direct arrhythmogenic and cardiotoxic effects on the myocardium combined with indirect cardiotropic effects mediated via activation of extracardial nerves. Aconitine demonstrated pronounced cholinolytic properties and blocked vagal arrhythmogenic effect.
Y R, Sheikh-Zade +2 more
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2000
Abstract Clinical A Ion channel syndrome (voltage-sensitive Na+ channels) B Acute encephalopathy (dystonia, confusion, death) The family Ranunculaceae contains a number of exception ally toxic herbaceous perennials, such as Aconitum napellus L. (monkshood), A. vulparia Reichb. ex Spreng (wolf’s bane)
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Abstract Clinical A Ion channel syndrome (voltage-sensitive Na+ channels) B Acute encephalopathy (dystonia, confusion, death) The family Ranunculaceae contains a number of exception ally toxic herbaceous perennials, such as Aconitum napellus L. (monkshood), A. vulparia Reichb. ex Spreng (wolf’s bane)
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Regioselective demethylation of aconitine
Tetrahedron Letters, 1994Abstract The regioselective demethylation of aconitine has been achieved with Lewis acids. Me 3 SiI afforded first 18- O -desmethyl- and then 16,18-di- O -desmethylaconitine, but AlCl 3 /NaI gave 16- O -desmethylaconitine first. The acetate and benzoate esters survived throughout these procedures. Aconitine decomposed on treatment with BBr 3 .
Ian S. Blagbrough +3 more
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THE BENZOYLOXY GROUP OF ACONITINE
Canadian Journal of Chemistry, 1963not available
Y. Tsuda, Léo Marion
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Tetrahedron Letters, 1994
Abstract The regioselective acylation of 18- O -desmethylaconitine has been achieved with isatoic anhydride to afford the corresponding anthranilate ester, an analogue of inuline. The aniline nitrogen was then incorporated into an S -methylsuccinimide moiety, to afford a novel methyllycaconitine/aconitine hybrid alkaloid.
David J. Hardick +3 more
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Abstract The regioselective acylation of 18- O -desmethylaconitine has been achieved with isatoic anhydride to afford the corresponding anthranilate ester, an analogue of inuline. The aniline nitrogen was then incorporated into an S -methylsuccinimide moiety, to afford a novel methyllycaconitine/aconitine hybrid alkaloid.
David J. Hardick +3 more
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2017
Aconitum napellus, monkswood, is the most poisonous of all plants – its roots especially so – because it produces the chemical aconitine. Aconitine is dangerous because it can be absorbed through the skin; just touching the leaves may lead to numbness in the fingers. There is no known antidote for aconitine.
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Aconitum napellus, monkswood, is the most poisonous of all plants – its roots especially so – because it produces the chemical aconitine. Aconitine is dangerous because it can be absorbed through the skin; just touching the leaves may lead to numbness in the fingers. There is no known antidote for aconitine.
openaire +1 more source