Results 111 to 120 of about 6,664,068 (391)

Single-Bone Forearm Salvage Procedure for a Child with Acquired Radial Clubhand in a Resource Limited Centre: A Case Report [PDF]

Malaysian Orthopaedic Journal, 2018
Acquired radial clubhand deformity can be a consequence of large bone gap left by premature extensive radius osteomyelitis sequestrectomy. Single-bone forearm reconstruction is a salvage procedure when other motionpreserving techniques are not ...
Sahdi H , Chan WH, Dollah NB , Entri A
doaj   +1 more source

Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M–Positive Lung Cancer and Acquired Resistance to Osimertinib

JAMA Oncology, 2018
Importance Osimertinib mesylate is used globally to treat EGFR-mutant non–small cell lung cancer (NSCLC) with tyrosine kinase inhibitor resistance mediated by the EGFR T790M mutation.
G. Oxnard, Yuebi Hu, K. Mileham, H. Husain, D. Costa, P. Tracy, N. Feeney, L. Sholl, S. Dahlberg, A. Redig, D. Kwiatkowski, M. Rabin, C. Paweletz, K. Thress, P. Jänne   +14 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Lifeboat for Failed Nasal Reconstructions: The Supraclavicular–Submental Sandwich Flap

Archives of Plastic Surgery
Many failures in total or subtotal nasal reconstruction result from an underestimation of the amount of skin required for an adequate result, especially for sufficient lining. Such planning errors usually lead to poor results, with exposure of structural
Michel L.H.T. Vaena, Kevin Sicalo, Caterina Goulart Alessio, Eduardo Pantoja Bastos   +3 more
doaj   +1 more source

Near full thickness macular hole with an intact overlying internal limiting membrane following resolution of fulminant acquired toxoplasma retinitis -A unique finding

Indian Journal of Ophthalmology, 2020
A 43-year-old immunocompetent male presented with focal macular retinitis with overlying vitritis in the right eye. His BCVA was counting fingers close to face.
Kalpana Babu, Dhwani Shah, M Bhagya, Krishna R Murthy   +3 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Marri, P.R., Ochman, H., Passel, M.W.J., van   +2 more
core   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

HIV Self-Testing: A Discussion on the Benefits, Limitations, and Implications for Public Health with a Focus on Poland

Diagnostics
Background/Objectives: A late HIV diagnosis represents a significant public health concern in Poland, with approximately 50% of patients being identified as late presenters (LPs), resulting in the delayed initiation of treatment.
Aleksandra Kozieł, Igor Domański, Aleksandra Szymczak, Tomasz Dudzik, Brygida Knysz, Bartosz Szetela   +5 more
doaj   +1 more source

Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults.

New England Journal of Medicine, 2015
BACKGROUND Community-acquired pneumonia is a leading infectious cause of hospitalization and death among U.S. adults. Incidence estimates of pneumonia confirmed radiographically and with the use of current laboratory diagnostic tests are needed ...
Seemalata Jain, W. Self, R. Wunderink, S. Fakhran, R. Balk, A. Bramley, C. Reed, Carlos G. Grijalva, E. Anderson, D. Courtney, J. Chappell, Chao Qi, E. Hart, Frank E. Carroll, C. Trabue, H. Donnelly, Derek J. Williams, Yuwei Zhu, S. Arnold, K. Ampofo, G. Waterer, M. Levine, S. Lindstrom, J. Winchell, J. Katz, D. Erdman, E. Schneider, L. Hicks, J. McCullers, A. Pavia, K. Edwards, L. Finelli   +31 more
semanticscholar   +1 more source