Results 141 to 150 of about 2,225,697 (249)

Public concerns over presumed metal and radionuclide pollution: testing a possible link to ovine hepatic melanosis in South Greenland. [PDF]

Environ Monit Assess
Hansen V, Nielsen OL, Mosbech A, Fabricius SD, Sonne C, Søndergaard J, Clausen DS, Johansen KL, van Beest F, Leifsson PS, Enemark HL.   +10 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluating hypothetical interventions effects on hospital-acquired infection outcomes with stacked probability visualization: R Shiny apps based on a multistate modelling approach. [PDF]

PLoS One
Gnimatin JP, Grodd M, Weber S, Hazard D, Wolkewitz M.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Tale of 2 Hospitals: Receiving Surgical Care at a Hospital with a Geriatric Surgical Pathway Improves Postoperative Outcomes. [PDF]

J Am Coll Surg
Jabour SM, Owodunni OP, Del Rosario SS, Bettick D, Khan F, Magnuson T, Gearhart SL.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Private Equity Acquisition and Buprenorphine Prescribing.

JAMA Netw Open
Holdaway T, Busch SH, Reimer J, Beetham T, Fiellin DA, King M.   +5 more
europepmc   +1 more source

Privately made firearm in the US: results from a national survey. [PDF]

Inj Epidemiol
Fletcher S, Azrael D, Miller M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Postpartum acquired hemophilia presenting as compartment syndrome: a diagnostic challenge in the emergency department. [PDF]

Int J Emerg Med
Mujahed W, Nama A, Kalish J, Nimer Q, Hahn B, Alpert EA.   +5 more
europepmc   +1 more source