Results 281 to 290 of about 7,180,133 (408)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

HIV pre-exposure prophylaxis (PrEP) – are we seeing the end of the HIV pandemic?

HIV & AIDS Review. International Journal of HIV-Related Problems
Bartosz Szetela, Aleksandra Szymczak, Hubert Ciepłucha, Marcin Czarnecki   +3 more
doaj   +1 more source

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Nature, 2012
S. Misale, R. Yaeger, S. Hobor, E. Scala, M. Janakiraman, D. Liska, E. Valtorta, R. Schiavo, M. Buscarino, G. Siravegna, K. Bencardino, A. Cercek, Ching-Tung Chen, S. Veronese, C. Zanon, A. Sartore-Bianchi, M. Gambacorta, M. Gallicchio, E. Vakiani, Valentina Boscaro, E. Medico, M. Weiser, S. Siena, F. Nicolantonio, D. Solit, A. Bardelli   +25 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transformer-based deep learning for early detection of intensive care unit-acquired bloodstream infection through multivariate time-series analysis. [PDF]

Digit Health
Peng JC, Liang JR, Zhu ML, Wang C, Gao Y.   +4 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Peer Review #1 of "Gastrointestinal transit time and heart rate variability in patients with mild acquired brain injury (v0.1)"

, 2018
Johannes Enevoldsen, Simon Tilma Vistisen, Klaus Krogh, Jørgen Feldbæk Nielsen, Karoline Knudsen, Henning Andersen, Johannes Enevoldsen, Simon Tilma Vistisen, Klaus Krogh, Jørgen Feldbæk Nielsen, Karoline Knudsen, Per Borghammer, Henning Andersen, H Abrahamsson, S Antov, I Bosaeus, Esc Aha, F Bracci, D Badiali, P Pezzotti, G Scivoletto, U Fuoco, Di Lucente, L, Petrelli Corazziari, E, L Degen, S Phillips, D Izzo, B Fischer, G Pau, U Ghoshal, V Sengar, D Srivastava, J Graff, K Brinch, J Madsen, G Grolemund, H Wickham, T Han, J Kim, B Kwon, H Jung, D Kim, I Moon, C-H Kao, S-P Changlai, P-U Chieng, Yen, T-C, O Keren, S Yupatov, M Radai, R Elad-Yarum, D Faraggi, S Abboud, H Ring, Z Groswasser, M King, S Lichtman, G Seliger, F Ehert, J Steinberg, K Knudsen, T Fedorova, A Bekker, P Iversen, K stergaard, K Krogh, P Borghammer, K Krogh, P Christensen, S Sabroe, S Laurberg, K Krogh, C Mosdal, S Laurberg, Y Lim, D Kim, M Lee, M Joo, M Majdan, D Plancikova, A Brazinova, M Rusnak, D Nieboer, V Feigin, A Maas, R Metelka, A Olsen, R Hetz, H Xue, K Aroom, D Bhattarai, E Johnson, S Bedi, C Cox, K Uray, P Stubbs, H Pallesen   +99 more
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Are Acquiring Firm Shareholders Better Off After An Acquisition Than They Were Before

, 1988
Ellen Magenheim, Dennis C. Mueller
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source