Results 61 to 70 of about 3,472,338 (345)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Efficacy of a Combined Treatment of Botulinum Toxin and Intensive Physiotherapy in Hereditary Spastic Paraplegia

Frontiers in Neuroscience, 2020
IntroductionThe Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and lower limbs (LL) weakness.
Gabriella Paparella, Marinela Vavla, Marinela Vavla, Lisa Bernardi, Giulia Girardi, Cristina Stefan, Andrea Martinuzzi, Andrea Martinuzzi   +7 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

International recommendations on the diagnosis and treatment of acquired hemophilia A

Haematologica, 2020
Acquired hemophilia A (AHA), a rare bleeding disorder caused by neutralizing autoantibodies against coagulation factor VIII (FVIII), occurs in both men and women without a previous history of bleeding.
A. Tiede, P. Collins, P. Knoebl, J. Teitel, C. Kessler, M. Shima, G. Di Minno, R. d’Oiron, P. Salaj, V. Jiménez‐Yuste, A. Huth‐Kühne, P. Giangrande   +11 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Improving hand hygiene compliance among healthcare workers: an intervention study in a Hospital in Guizhou Province, China

Brazilian Journal of Infectious Diseases, 2016
Objective: Hand hygiene (HH) is a critical component for controlling hospital-acquired infection (HAI). The present study was designed to develop an intervention approach to improve compliance with HH among healthcare workers in a hospital setting ...
Xia Mu, Yan Xu, Tingxiu Yang, Ji Zhang, Chong Wang, Wei Liu, Jing Chen, Luyu Tang, Huai Yang   +8 more
doaj  

Community-acquired pneumonia requiring hospitalization among U.S. children.

New England Journal of Medicine, 2015
BACKGROUND Incidence estimates of hospitalizations for community-acquired pneumonia among children in the United States that are based on prospective data collection are limited. Updated estimates of pneumonia that has been confirmed radiographically and
Seemalata Jain, Derek J. Williams, S. Arnold, K. Ampofo, A. Bramley, C. Reed, C. Stockmann, E. Anderson, Carlos G. Grijalva, W. Self, Yuwei Zhu, Anami R. Patel, W. Hymas, J. Chappell, R. Kaufman, J. Kan, David M. Dansie, N. Lenny, D. Hillyard, L. Haynes, M. Levine, S. Lindstrom, J. Winchell, J. Katz, D. Erdman, E. Schneider, L. Hicks, R. Wunderink, K. Edwards, A. Pavia, J. McCullers, L. Finelli   +31 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Edinilmiş petit fıtığı birincil tipinde yama onarım tekniklerinin kombinasyonu

Cukurova Medical Journal, 2018
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Alper PARLAKGÜMÜŞ, Ali EZER
doaj   +1 more source

The national cost of hospital‐acquired pressure injuries in the United States

International Wound Journal, 2019
Our objective was to estimate the US national cost burden of hospital‐acquired pressure injury (HAPI) using economic simulation methods. We created a Markov simulation to estimate costs for staged pressure injuries acquired during hospitalisation from ...
W. Padula, Benjo A Delarmente
semanticscholar   +1 more source