Results 71 to 80 of about 3,472,338 (345)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

Clinical Cancer Research, 2013
Purpose: All patients with EGF receptor (EGFR)–mutant lung cancers eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). Smaller series have identified various mechanisms of resistance, but systematic evaluation of a large ...
H. Yu, M. Arcila, N. Rekhtman, C. Sima, M. Zakowski, W. Pao, M. Kris, V. Miller, M. Ladanyi, Gregory Riely   +9 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Thrombophilia in young adults with ischemic stroke: an overview

Neurologijos seminarai, 2019
Thrombophilia broadly defines inherited or acquired coagulation disorders associated with increased tendency to form intravascular thrombi. Evaluation for thrombophilia in young patients with cryptogenic stroke is a frequent clinical question.
R. Mineikytė , L. Kryžauskaitė , K. Ryliškienė   +2 more
doaj   +1 more source

Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M–Positive Lung Cancer and Acquired Resistance to Osimertinib

JAMA Oncology, 2018
Importance Osimertinib mesylate is used globally to treat EGFR-mutant non–small cell lung cancer (NSCLC) with tyrosine kinase inhibitor resistance mediated by the EGFR T790M mutation.
G. Oxnard, Yuebi Hu, K. Mileham, H. Husain, D. Costa, P. Tracy, N. Feeney, L. Sholl, S. Dahlberg, A. Redig, D. Kwiatkowski, M. Rabin, C. Paweletz, K. Thress, P. Jänne   +14 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Single-stage nasolabial interpolation flap for reconstructing defects of the nose and inner corner of the eye [PDF]

Revista Brasileira de Cirurgia Plástica, 2019
Introduction: Interpolation flaps are effective surgical options for reconstructing skin defects in various areas of the body, including the face. The proposed flap does not require postoperative care with the pedicle exposed and can be performed in a ...
Jefferson Di Lamartine Galdino Amaral, Ronan Caputi Silva Dias, Amanda Costa Campos, Rafael Sabino Caetano Costa, Suellen Vieira Da-Silva, Anderson de Azevedo Damasio, Juldásio Galdino de Oliveira Júnior, José Carlos Daher   +7 more
doaj   +1 more source

Acquired Nystagmus [PDF]

Archives of Ophthalmology, 2000
Traditionally, acquired forms of nystagmus have been classified in descriptive terms based on their clinical features and recorded waveforms. In the past 20 years, the mechanisms of several major forms of nystagmus have been elucidated; animal and mathematical models for these ocular oscillations have been developed.
J S, Stahl, L, Averbuch-Heller, R J, Leigh   +2 more
openaire   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source