Results 11 to 20 of about 9,561 (186)

Acquired Hemophilia A Secondary to an Immune Checkpoint Inhibitor: A Case Report

JTO Clinical and Research Reports, 2022
We report a case of a patient with extensive-stage SCLC who developed acquired hemophilia A during maintenance atezolizumab therapy. The patient initially presented with asymptomatic anemia, a prolonged acquired prothrombin time, and factor VIII (FVIII ...
James Fletcher, MBBS, Robert Bird, MBBS, Andrew J.W. McLean, MBBS, Kenneth O’Byrne, MD, Wen Xu, MBBS   +4 more
doaj   +1 more source

Acquired Hemophilia ‘A’ – An Uncommon Condition Presented with Common Manifestations

National Board of Examinations Journal of Medical Sciences, 2023
Hemophilia A is usually a congenital bleeding disorder, which manifest in males due to its X linked recessive pattern of inheritance. It commonly presents with bruises, uncontrolled bleeding post minor trauma or post circumcision, knee swelling etc ...
Deepak S. Laddhad, Vinayak Hingane, Bantu Ruthvick, Shubham Rajkumar Agrawal, Pavan Shrikrishna Gadge   +4 more
doaj   +1 more source

WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT

International Journal of Infectious Diseases, 2023
Intro: Acquired hemophilia is an atypical pathology of SARS-CoV-2 infection, which could be variant associated. Here, we share a sequence of the SARS-CoV-2 genome from patient with COVID-19 acquired haemophilia.
U.A. Zainulabid, A. Aslam, M. Hussain, I. Ibrahim, P. Periyasamy, N. Kamarudin, H.F. Ahmad   +6 more
doaj   +1 more source

Acquired hemophilia A that required surgical hemostasis of hematomas occupying oral cavity: a case report

Journal of Medical Case Reports, 2021
Background Acquired hemophilia A is a rare coagulopathy caused by inhibitors of blood coagulation factor VIII. Patients with acquired hemophilia A have a higher mortality risk (5–10%) than those with congenital hemophilia.
Keigo Maeda, Shinsuke Yamamoto, Naoki Taniike, Toshihiko Takenobu   +3 more
doaj   +1 more source

A case of acquired hemophilia A and bullous pemphigoid following SARS-CoV-2 mRNA vaccination

Journal of the Formosan Medical Association, 2022
Acquired hemophilia is a rare disease resulting from autoantibodies against endogenous factor VIII (FVIII), which associates with bleeding and a high mortality rate. The pathophysiology is still unclear.
Pei-An Fu, Chien-Wei Chen, Ya-Ting Hsu, Kai-Che Wei, Peng-Chan Lin, Tsai-Yun Chen   +5 more
doaj   +1 more source

Acquired hemophilia A and plasma cell neoplasms: a case report and review of the literature

Journal of Medical Case Reports, 2020
Background Acquired hemophilia A is a rare autoimmune disease with clinically often significant bleeding diathesis resulting from circulating autoantibodies inhibiting coagulation factor VIII.
Katarzyna A. Jalowiec, Martin Andres, Behrouz Mansouri Taleghani, Albulena Musa, Martina Dickenmann, Anne Angelillo-Scherrer, Alicia Rovó, Johanna A. Kremer Hovinga   +7 more
doaj   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Literature review and clinical observation of acquired idiopathic hemophilia with a new missense mutation in the factor VIII gene (His2026Arg) [PDF]

Терапевтический архив, 2018
The article provides review of possible mechanisms of inhibitor coagulopathies, in particular of acquired hemophilia A. This pathology is an extremely rare disease occurring in 1-2 cases in 1 million per year. In the present study we provide data for two
V I ERSHOV, I Yu GADAEV, D A BUDANOVA, F G PERINA, V L SURIN, V V SALOMASHKINA, O S PSHENICHNIKOVA, N I ZOZULYA   +7 more
doaj   +1 more source

Acquired Hemophilia A with Gastrointestinal Bleeding [PDF]

Clinical Endoscopy, 2020
Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy.
Narae Park, Jin Seok Jang, Jae Hwang Cha
doaj   +1 more source

New Developments in Diagnosis and Management of Acquired Hemophilia and Acquired von Willebrand Syndrome

HemaSphere, 2021
Acquired hemophilia A and acquired von Willebrand syndrome are rare, but life-threatening bleeding disorders that require prompt diagnosis and treatment by hematologists.
Frank W. G. Leebeek
doaj   +1 more source