Results 11 to 20 of about 283 (122)

Investigation of Antimuscarinic Receptor Autoantibodies in Patients with Acquired Idiopathic Generalized Anhidrosis

Internal Medicine, 2013
The autoimmune mechanism is considered to play an important role in the development of acquired idiopathic generalized anhidrosis (AIGA), and muscarinic M3 receptors (M3Rs) on eccrine glands are possible autoimmune targets. We investigated the existence of autoantibodies against M3Rs in AIGA patients.We immunostained M3R-expressing cultured cells with ...
Masato Asahina, Satoshi Kuwabara, Kenji Sano   +2 more
exaly   +4 more sources

Recurrent Pain and Heat Retention as Indications of Acquired Idiopathic Generalized Anhidrosis

Annals of Internal Medicine: Clinical Cases
Acquired idiopathic generalized anhidrosis is a rare disease worldwide. It is typically seen in young men. The patient in this case has generalized anhidrosis.
Yasutaka Yanagita, Mutsuka Kurihara, Daiki Yokokawa, Takanori Uehara, Masatomi Ikusaka   +4 more
doaj   +2 more sources

Molecular mechanisms of acquired idiopathic generalized anhidrosis: differential gene expression and potential therapeutic targets

Discover Applied Sciences
Eccrine sweat glands are essential for thermoregulation. Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder characterized by the absence of sweating, leading to severe complications like heatstroke and skin dryness.
Sanjukta Dasgupta
doaj   +2 more sources

Cholinergic Urticaria Associated with Acquired Generalized Hypohidrosis: Two Case Reports and Review of the Literature

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2021
Cholinergic urticaria is a relatively common condition defined by itching, redness and whealing induced by exercise and passive warming. In turn, acquired idiopathic generalized anhidrosis is a rare disorder of unknown pathogenesis, characterized by an ...
Cíntia Cruz, Filipa Alexandra Matos Tavares Semedo, Elza Maria Morgado Tomaz, Luís Miguel Nabais Borrego   +3 more
doaj   +1 more source

Clinical and genetic characteristics of three patients with congenital insensitivity to pain with anhidrosis: Case reports and a review of the literature. [PDF]

Mol Genet Genomic Med
Patients with congenital insensitivity to pain with anhidrosis typically present with cellulitis in their fingers and toes, often leading to amputation due to self‐mutilating behavior. Osteodystrophy can result from a history of recurrent infections and surgeries.
Cho JH, Hwang S, Kwak YH, Yum MS, Seo GH, Koh JY, Ju YS, Yoon JH, Kang M, Do HS, Kim S, Kim GH, Bae H, Lee BH.   +13 more
europepmc   +2 more sources

Direct and indirect action modes of acetylcholine in cholinergic urticaria

Allergology International, 2021
Cholinergic urticaria (CholU) manifests small, itchy and/or painful wheals occurring upon perspiration and mechanically involving acetylcholine (Ach).
Yoshiki Tokura
doaj   +1 more source

Clinical and histological characterization of transient dermal pain triggered by sweating stimuli

Allergology International, 2022
Background: Tingling dermal pain triggered by sweating impairs the lives of patients with cholinergic urticaria and generalized anhidrosis. However, dermal pain evoked by sweating stimuli has been under investigated.
Shunsuke Takahagi, Mayumi Okamoto, Kaori Ishii, Akio Tanaka, Hayato Mizuno, Naoe Harada, Nozomi Yanagida, Michihiro Hide   +7 more
doaj   +1 more source

Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis

Journal of the European Academy of Dermatology and Venereology, Volume 37, Issue 10, Page 2124-2132, October 2023., 2023
Abstract Background Acquired idiopathic generalized anhidrosis (AIGA) leads to heat intolerance due to the loss or reduction in thermoregulatory sweating over an extensive area of the body. The pathomechanism of AIGA is still unclear but is believed to be autoimmune. Objectives We investigated the clinical and pathological features of inflammatory AIGA
K. Sano, M. Asahina, N. Araki, T. Uehara, M. Iwaya, R. Okuyama   +5 more
wiley   +1 more source

Sudden onset anhidrosis in an otherwise healthy male

Skin Health and Disease, Volume 3, Issue 4, August 2023., 2023
Sudden onset anhidrosis in an otherwise healthy 59‐year‐old Chinese male who presented to the dermatology department with a 3‐month history of a sudden lack of sweat production after picking up long distance cycling for 2 months Abstract Acquired idiopathic generalised anhidrosis (AIGA) is a rare disorder that is characterised by sudden onset ...
Clara Michelle Tan Hwei Sian Tan, Rayson Lee, Janet Pei Ling Dua   +2 more
wiley   +1 more source

Poor performance in the horse: Diagnosing the non‐orthopaedic causes

Equine Veterinary Education, Volume 35, Issue 4, Page 208-224, April 2023., 2023
Summary Poor performance and gait deficits in the equine athlete are most commonly caused by lameness of orthopaedic origin; however, there are numerous other potential sources that should be taken into consideration. This review describes the clinical signs and diagnostic tests for non‐orthopaedic causes of poor performance and gait deficits in the ...
Katherine L. Ellis, Erin K. Contino, Yvette S. Nout‐Lomas   +2 more
wiley   +1 more source