Results 141 to 150 of about 25,450 (246)

Alternative Lead ECG Placements

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Alternative ECG lead placements can improve diagnostic yield when the standard 12‐lead ECG is suboptimal or infeasible. This review summarizes practical, scenario‐driven modifications (right‐sided, posterior, seated/prone, Lewis, Fontaine, torso‐based, and monitoring configurations) to better detect ischemia, right ventricular disease/ARVD, and ...
José Luis Morales‐Arteaga, Amin Meghdadi, Derek Wu, Abdullah Bhuiyan, Nicole Langleben, Cengiz Burak, Emily Wilson, Ashley Pellerito, David Aristizábal, Keanu Razzaghi, Juan Maria Farina, Shyla Gupta, Adrian Baranchuk   +12 more
wiley   +1 more source

Case report: A 56-year-old woman presenting with torsades de pointes and cardiac arrest associated with levosimendan administration and underlying congenital long QT syndrome type 1

Heliyon
Torsades de Pointes (TdP) is a malignant polymorphic ventricular tachycardia with heart rate corrected QT interval (QTc) prolongation, which may be attributed to congenital and acquired factors.
Fengyan Zha, Xing Li, Hui Yin, Di Huang, Yu Du, Chuzhi Zhou   +5 more
doaj   +1 more source

Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome [PDF]

, 2015
Victoria Williams, Carl J. Cresswell, Gerhard Ruspi, Tao Yang, Thomas C. Atak, Matthew McLoughlin, Christiana D. Ingram, Andrea H. Ramirez, Dan M. Roden, Martin Armstrong   +9 more
openalex   +1 more source

Clinical Pharmacology and Translational Science Considerations in the Development of Dual‐Payload Antibody Drug Conjugates

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have evolved in the last decade or two from carrying a single chemotherapy payload to carrying highly potent tubulin inhibitors and DNA damaging agents. While the latter have shown success in the clinic, efficacy has been constrained by therapeutic resistance, limited tumor penetration, and suboptimal immune ...
Paulien Ravenstijn, Toru Kakinuma, Salaheldin Hamed, Takeshi Kadokura, Yohei Okada, Srinivasu Poondru   +5 more
wiley   +1 more source

Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén, Aleksi Winstén, Konsta Teppo, Timo Pohjonen, Jari Laukkanen, Arto Mannermaa, Teemu J. Niiranen, Joonatan Palmu   +7 more
wiley   +1 more source

Acquired Long QT Syndrome Manifesting with Torsades de Pointes in a Patient with Panhypopituitarism due to Radiotherapy [PDF]

, 2013
Dae Gil Kang, Sung Eun Kim, Myoung Soo Park, Eun Jung Kim, Jun Hee Lee, Dae Gyun Park, Kyoo Rok Han, Dong Jin Oh   +7 more
openalex   +1 more source

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]

, 2018
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava, Clancy, Colleen E, DeMarco, Kevin R, Noskov, Sergei Y, Vorobyov, Igor   +4 more
core  

The Calcium/Calmodulin/Kinase System and Arrhythmogenic Afterdepolarizations in Bradycardia-Related Acquired Long-QT Syndrome [PDF]

, 2009
Xiaoyan Qi, Yung‐Hsin Yeh, Denis Chartier, Ling Xiao, Yukiomi Tsuji, Bianca J.J.M. Brundel, Itsuo Kodama, Stanley Nattel   +7 more
openalex   +1 more source

Regulation of Kv11.1 Potassium Channel C-Terminal Isoform Expression by the RNA-Binding Proteins HuR and HuD

, 2018
The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

Roles of atrial arrhythmias in triggering torsade de pointes in patients with acquired long QT syndrome [PDF]

, 2023
Ryota Tochibora, Nobumasa Takasugi, Susumu Endo, Akihiro Yoshida, Takuya Watanabe, Tomoko Kawaguchi, Mieko Takasugi, Yasuhiro Yamada, Hiromitsu Kanamori, Hiroyuki Okura   +9 more
openalex   +1 more source