Results 61 to 70 of about 45,337 (219)

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model

, 2004
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a
Cherry E. M., Diego J. M. D., Hervé Henry, Wouter-Jan Rappel   +3 more
core   +1 more source

The U wave in atrial fibrillation [PDF]

, 2015
The U wave in ECGs of patients is difficult to observe because it is hidden under the atrial fibrillatory wave. Measurement and characteristics of the U wave in atrial fibrillation have not previously been described. Beat averaging was used to reveal the
Bourke, John P, Langley, Philip, Murray, Alan   +2 more
core   +1 more source

[The risk of acquired long QT syndrome during a coronavirus epidemic. Focus on hydroxychloroquine].

Orvosi Hetilap, 2020
Hydroxychloroquine is an immunomodulatory agent used primarily in malaria, lupus erythematosus, and rheumatoid arthritis. The authors summarize the potential proarrhythmic effect of this formulation and the key signs of drug-induced long QT syndrome. The
J. Tomcsányi, Kristóf Tomcsányi
semanticscholar   +1 more source

QT interval prolongation in Takotsubo syndrome: a frightening feature with no major prognostic impact

Monaldi Archives for Chest Disease, 2023
Despite the frequent and often severe repolarization abnormalities seen in Takotsubo syndrome (TTS), the underlying mechanism of life-threatening arrhythmias is incompletely understood, and the risk remains uncertain. TTS is considered a potential cause
Ana Isabel Pinho, Cátia Oliveira, Luís Daniel Santos, Catarina Marques, André Cabrita, Paula Dias, Gonçalo Pestana, Carla Sousa, Rui André Rodrigues   +8 more
doaj   +1 more source

Acquired long QT syndrome, manifesting in the first complex after a ventricular extrasystole

Journal of Arrhythmology, 2021
A case report of unusual QT interval prolongation after ventricular premature beat is presented.
O. Kononenko, S. Zenin, A. V. Fedoseenko, I. M. Felikov, O. V. Pyataeva, M. Ermolaeva   +5 more
semanticscholar   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

The long-QT syndrome: A silent killer [PDF]

, 2010
Introduction: Sudden cardiac death is a striking phenomenon, affecting seemingly healthy individuals without warning. The long-QT syndrome is a common cause of sudden cardiac death that can either be inherited or acquired.
Crowley, Claire
core   +1 more source

Right ventricular epicardial arrhythmogenic substrate in long-QT syndrome patients at risk of sudden death

Europace, 2023
Aims The long-QT syndrome (LQTS) represents a leading cause of sudden cardiac death (SCD). The aim of this study was to assess the presence of an underlying electroanatomical arrhythmogenic substrate in high-risk LQTS patients.
C. Pappone, G. Ciconte, L. Anastasia, F. Gaita, E. Grant, E. Micaglio, E. Locati, Ž. Ćalović, G. Vicedomini, V. Santinelli   +9 more
semanticscholar   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). [PDF]

, 2001
Voltage-gated potassium channels provide tightly Controlled, ion-specific pathways across membranes and are key to the normal function of nerves muscles. They arise from the assembly of four pore-forming proteins called alpha-subunits.
Abbott, GW, Goldstein, SA
core