Results 81 to 90 of about 222 (145)
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang +12 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 4, August 2026.Catheter ablation for ventricular tachycardia showed comparable acute procedural success and complication rates in patients with and without electrical storm. However, electrical storm was associated with higher in‐hospital mortality, long‐term mortality, and ventricular tachycardia recurrence, supporting its role as a marker of adverse prognosis ...
Ahmad Jalil +12 more
wiley +1 more source
HeliyonTorsades de Pointes (TdP) is a malignant polymorphic ventricular tachycardia with heart rate corrected QT interval (QTc) prolongation, which may be attributed to congenital and acquired factors.
Fengyan Zha +5 more
doaj +1 more source
Journal of Arrhythmia, Volume 42, Issue 4, August 2026.In this systematic review and meta‐analysis of seven studies involving 1366 patients, elevated T‐wave amplitude variability (TAV) was associated with a 2.5‐fold higher risk of adverse cardiovascular outcomes. These findings support TAV as a marker of ventricular repolarization instability for long‐term risk stratification.
Yoshihiro Sobue +5 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres +2 more
wiley +1 more source
Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II
Clinical and Experimental Pharmacology and Physiology, Volume 53, Issue 8, August 2026.ABSTRACT Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)‐mediated cardiac hypertrophy pathogenesis, with particular focus on its potential regulation through inflammatory pathways and oxidative stress mechanisms.
Qiming Tan +5 more
wiley +1 more source
Allergy, Volume 81, Issue 8, Page 2744-2774, August 2026.ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas +128 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 15, Page 4145-4162, August 2026.Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata +4 more
wiley +1 more source