Results 61 to 70 of about 8,451,399 (181)

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

Sleep-Associated Torsades de Pointes: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2017
Torsades de Pointes (TdP) is a polymorphic ventricular tachycardia that occurs in the presence of an acquired or congenital long QT syndrome (LQTS). We present the case of a 57 year-old man with end-stage renal disease on methadone maintenance in which ...
Guy Carmelli, Ian S. deSouza
doaj   +1 more source

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

, 2003
Modulating effects of age and gender on the clinical course of long QT syndrome by ...
Vincent GM, Zhang L, Lehmann MH, Timothy K, International Long QT Syndrome Registry, PRIORI, SILVIA GIULIANA, Hall WJ, SCHWARTZ, PETER, Moss AJ, Peterson DR, Benhorin J, Locati EH, Robinson JL, Zareba W, Towbin JA, Andrews ML, Medina A, Napolitano C   +17 more
core  

Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation

, 2021
Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus ...
Kevin Llinás-Caballero, Carlos Alberto Calderon-Ospina, Julián Miguel Corso-Ramirez, Camilo Alberto Dominguez-Dominguez, Dora Janeth Fonseca-Mendoza, Daniela Baracaldo-Santamaría, Carlos Martín Restrepo, Corso-Ramirez, Julián Miguel, Martín Restrepo, Carlos, Baracaldo-Santamaría, Daniela, Calderon-Ospina, Carlos Alberto, Llinás-Caballero, Kevin, Dominguez-Dominguez, Camilo Alberto, Fonseca-Mendoza, Dora Janeth   +13 more
core   +1 more source

Safety and Utility of Smartphone‐Based Heart Monitors in Pediatric Patients With Cardiovascular Implantable Electronic Devices

Journal of Cardiovascular Electrophysiology, EarlyView.
Smartphone heart monitors in pediatric CIEDs: A pilot study. Smartphone heart monitors did not induce EMI in children with CIEDs, enabling reliable heart rate measurement and accurate identification of ventricular non‐captures. ABSTRACT Background Portable heart monitors enable on‐demand electrocardiogram (ECG) recordings and enhance symptom‐rhythm ...
Chun‐Lok Ho, Sit‐Yee Kwok, Sabrina S. L. Tsao, Yiu‐Fai Cheung   +3 more
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Long-QT syndrome after age 40 [PDF]

, 2008
Long-QT syndrome after age ...
Ackerman MJ, Goldenberg I, Qi M, Zhang L., Polonsky S, Vincent GM, PRIORI, SILVIA GIULIANA, SCHWARTZ, PETER, Moss AJ, Peterson DR, Benhorin J, Locati EH, Bradley J, Robinson JL, Zareba W, Kaufman ES, Andrews ML, Towbin JA, McNitt S, Napolitano C   +19 more
core  

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Tormenta eléctrica y torsade de pointes asociados a tratamiento con antimoniales en un paciente con leishmaniasis cutánea

Revista Colombiana de Cardiología, 2018
Resumen: La toxicidad por antimoniales puede comprometer múltiples sistemas y llega a ser potencialmente fatal. Se presenta el caso de un joven militar quien durante el tratamiento de su segundo episodio de leishmaniasis cutánea presentó toxicidad ...
Laura Arcos, Carlos Rincón, Diego Vanegas, Ramón Medina   +3 more
doaj   +1 more source