Results 151 to 160 of about 515,071 (299)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Sociological Representations of Apartments in Korean Thrillers [PDF]

International Journal of Korean History, 2018
Pierce Conran
doaj   +1 more source

Real-life application of respiratory oscillometry in pediatric asthma outpatient care: Feasibility and methodological aspects. [PDF]

Physiol Rep
Heijkenskjöld Rentzhog C, Malinovschi A, Alving K.   +2 more
europepmc   +1 more source

CEO Preferences and Acquisitions [PDF]

This paper explores the impact of target CEOs’ retirement preferences on the incidence, the pricing, and the outcomes of takeover bids. Mergers frequently force target CEOs to retire early, and CEOs’ private merger costs are the forgone benefits of ...
Dirk Jenter, Katharina Lewellen
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Accelerated 3D MRI for ARIA monitoring in Alzheimer's disease. [PDF]

Alzheimers Dement
Rosa-Grilo M, Mallon D, Thomas DL, Beament M, Chughtai HR, Liu W, Magill N, Malone IB, Meyer H, Parker GJM, Triantafyllou C, Barkhof F, Fox NC, Mummery CJ.   +13 more
europepmc   +1 more source

The Performance of the European Market for Corporate Control: Evidence from the 5th Takeover Wave [PDF]

For the 5th takeover wave, European M&As were expected to create significant takeover value: the announcement reactions were strongly positive for target shareholders (more than 35%) and the bidding shareholders also expected to gain a small though ...
Martynova, M., Renneboog, L.D.R.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Private Equity in Autism Services. [PDF]

JAMA Pediatr
Arnold DR, Reddy M, Cantor J, McBain RK, Yu H, Whaley CM, Singh Y.   +6 more
europepmc   +1 more source

Incentives for Partial Acquisitions and Real Market Concentration [PDF]

We analyze the incentives of a controlling shareholder of a firm to acquire, directly or indirectly through his firm, shares in a competitor. We charaterize the conditions under which these partial acquisitions as well as the equilibrium toehold and its ...
Marie-Cécile Fagart, Patricia Charléty, Saïd Souam   +2 more
core