Results 1 to 10 of about 32,445 (205)

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis [PDF]

Frontiers in Neurology, 2018
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental ...
Melissa Tully, Melissa Tully, Jonathan Tang, Jonathan Tang, Lingxing Zheng, Lingxing Zheng, Glen Acosta, Ran Tian, Ran Tian, Lee Hayward, Nicholas Race, Nicholas Race, David Mattson, Riyi Shi, Riyi Shi   +14 more
doaj   +3 more sources

Origin and Fate of Acrolein in Foods

Foods, 2022
Acrolein is a highly toxic agent that may promote the occurrence and development of various diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main routes of human exposure to acrolein.
Kaiyu Jiang, Jie Zheng, Juanying Ou
exaly   +3 more sources

Comprehensive transcriptome sequencing and biochemical studies revealed that acrolein induced lung injury in BEAS-2B cells and male rats through the lncRNA MIR155HG/miR-155-5p/CD200R1 and Nrf2/SLC7A11/GPX4 ferroptosis pathways [PDF]

Redox Biology
Acrolein is a significant high priority hazardous air pollutant. This research explore the relationship of acrolein-induced ferroptosis with the pathogenesis of lung injury by combining cellular, transcriptome, and animal-level studies.
Dan Liu, Hui Yu, Zhicun Liu, Le Wang, Dawo Liu, Xiangyu Cao   +5 more
doaj   +2 more sources

Adverse effects of acrolein, a ubiquitous environmental toxicant, on muscle regeneration and mass

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Acrolein is an extremely electrophilic aldehyde. Increased urinary acrolein adducts have been found in type 2 diabetic patients and people with a smoking habit.
Ching-Chia Wang, Ding-Cheng Chan, Chen-Yuan Chiu   +2 more
exaly   +2 more sources

NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein [PDF]

Scientific Reports
Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at the mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e.
Tomoaki Hirakawa, Megumi Taniuchi, Yoko Iguchi, Sudarma Bogahawaththa, Kiko Yoshitake, Shanika Werellagama, Takeshi Uemura, Tadayuki Tsujita   +7 more
doaj   +2 more sources

Molecular Characteristics of Toxicity of Acrolein Produced from Spermine

Biomolecules, 2023
Acrolein (CH2=CH-CHO), an unsaturated aldehyde produced from spermine, is one of the major contributors to oxidative stress. Acrolein has been found to be more toxic than reactive oxygen species (H2O2 and •OH), and it can be easily conjugated with ...
Keiko Kashiwagi, Kazuei Igarashi
doaj   +1 more source

Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity

Scientific Reports, 2021
Abnormal accumulation of acrolein, an α, β unsaturated aldehyde has been reported as one pathological cause of the CNS neurodegenerative diseases. In the present study, the neuroprotective effect of selumetinib (a MEK–ERK inhibitor) on acrolein-induced ...
Hui-Ju Huang, Hsiang-Tsui Wang, Ting-Yu Yeh, Bo-Wei Lin, Young-Ji Shiao, Yu-Li Lo, Anya Maan-Yuh Lin   +6 more
doaj   +1 more source

Acrolein induces endoplasmic reticulum stress and causes airspace enlargement. [PDF]

PLoS ONE, 2012
BACKGROUND: Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary and systemic effects of acrolein. Here we test the hypothesis whether systemic administration of
Yoshiaki Kitaguchi, Laimute Taraseviciene-Stewart, Masayuki Hanaoka, Ramesh Natarajan, Donatas Kraskauskas, Norbert F Voelkel   +5 more
doaj   +1 more source

Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Translational Neurodegeneration, 2021
Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor.
Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi   +7 more
doaj   +1 more source

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +1 more source