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iPLA2β Protects Retinal Pigment Epithelium From Ferroptosis in a Sodium Iodate-Induced Model of Dry AMD. [PDF]

Invest Ophthalmol Vis Sci
Suzuki T, Terao R, Nagahara M, Hayashi K, Azuma K, Shinzawa K, Moriwaki K, Shiraya T, Honjo M, Ueta T.   +9 more
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Acrolein health effects

Toxicology and Industrial Health, 2008
AbstractAcrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant. The general population is exposed to acrolein via smoking, second-hand smoke, exposure to wood and plastic smoke.
O, Faroon, N, Roney, J, Taylor, A, Ashizawa, M H, Lumpkin, D J, Plewak   +5 more
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Mutagenicity of acrolein and acrolein-induced DNA adducts

Toxicology Mechanisms and Methods, 2010
Acrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with deoxyguanosine generates alpha-hydroxy-1, N(2)-propano-2'-deoxyguanosine (alpha-HOPdG) and gamma-hydroxy-1, N(2)-propano-2'-deoxyguanosine (gamma-HOPdG) adducts. These two DNA adducts behave differently in mutagenicity. gamma-HOPdG is the major DNA adduct and it can lead to
Xing-yu, Liu, Mao-xiang, Zhu, Jian-ping, Xie   +2 more
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Acrolein and cell cycle

Toxicology Letters, 1982
Acrolein, a potent cilioinhibitor of cigarette smoke was tested on synchronously dividing cultures. Mitosis could be blocked whenever the addition of acrolein was made during the cell cycle but this effect was totally reversible (between 0.06 microgram/ml to 1 microgram/ml).
F, Marano, S, Puiseux-Dao
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Quantitation of Acrolein–Protein Adducts: Potential Biomarker of Acrolein Exposure

Journal of Toxicology and Environmental Health, Part A, 2004
Acrolein, an alpha,beta-unsaturated aldehyde, is a ubiquitous environmental toxic pollutant. Because of potential human exposure, there is a need for a sensitive, reliable, and specific method to monitor acrolein exposure. Acrolein is a potent electrophile and reacts with proteins mainly through Michael addition reaction, leading to acrolein-protein ...
Hui, Li, Jianling, Wang, Bhupendra, Kaphalia, G A S, Ansari, M Firoze, Khan   +4 more
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Acrolein

Cold Spring Harbor Protocols, 2006
Patrick H. M. Delanghe, Mark Lautens, Cody Timmons, S. R. S. Saibabu Kotti, Guigen Li   +4 more
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Phagocidal effects of acrolein

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Acrolein inactivated bacteriophages T5 and ΦX174 as well as the infectivity of ΦX174 DNA to spheroplast. The degree of inactivation of T5 by acrolein was less than that by oxidized spermine. The degree of inactivation of phage ΦX174 by acrolein was similar to that by a combined mixture of acrolein and putrescine, whereas the infectivity of ...
K, Nishimura, T, Komano, H, Yamada
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Acrolein – a pulmonary hazard

Molecular Nutrition & Food Research, 2011
AbstractAcrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke. More plentiful in cigarette smoke than polycyclic aromatic hydrocarbons (PAH), acrolein can adduct tumor suppressor p53 (TP53) DNA and may contribute to TP53‐mutations in lung cancer. Acrolein is also generated endogenously at sites of
Kiflai, Bein, George D, Leikauf
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